机构：[1]State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China,[2]Key Laboratory of Virology of Guangzhou, Institute of Medical Microbiology, Jinan University, Guangzhou, China,[3]Center for Animal Experiment, Guangzhou University of Chinese Medicine, Guangzhou, China,[4]Guangdong LongFan Biological Science and Technology, Foshan, China,[5]Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou, China广东省中医院
Dengue virus (DENV) infection causes several diseases ranging from dengue fever to life-threatening dengue hemorrhagic fever and dengue shock syndrome characterized by endothelial dysfunction, vascular leakage, and shock. Here, we identify a potential mechanism by which DENV induces tissue injury and vascular leakage by promoting the activation of interleukin (IL)-1 beta. DENV facilitates IL-1 beta secretion in infected patients, mice, human peripheral blood mononuclear cells (PBMCs), mouse bone marrow-derived macrophages (BMDMs), and monocyte-differentiated macrophages (THP-1) via activating the NLRP3 inflammasome. The accumulated data suggest that IL-1 beta probably induces vascular leakage and tissue injury in interferon-alpha/beta receptor 1 deficient C57BL/6 mice (IFNAR(-/-) C57BL/6), whereas IL-1 receptor antagonist (IL-1RA) alleviates these effects of IL-1 beta. Finally, administration of recombinant IL-1 beta protein results in vascular leakage and tissue injury in C57BL/6 mice. Together, the accumulated results demonstrate that IL-1 beta contributes to DENV-associated pathology and suggest that IL-1RA acts as a potential agent for the treatment of DENV-associated diseases.
基金：
National Natural Science
Foundation of China (Grant Numbers 81730061, 31800147,
81803813, and 81973549), the National Health and Family
Planning Commission of the People’s Republic of China,
National Mega Project on Major Infectious Disease Prevention
(Grant Numbers 2017ZX10103005 and 2017ZX10202201),
Guangdong Province “Pearl River Talent Plan” Innovation
and Entrepreneurship Team Project (Grant Number
2017ZT07Y580), GZUCM First-Class Universities and Top
Disciplines Projects (2019KYTD102 and A1-AFD018191A17),
Science and Technology Planning Project of Guangzhou
(No. 201804010029), and Innovative Program of State Key
Laboratory of Virology (No. 2016KF001).
第一作者机构：[1]State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China,
共同第一作者：
通讯作者：
通讯机构：[1]State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China,[2]Key Laboratory of Virology of Guangzhou, Institute of Medical Microbiology, Jinan University, Guangzhou, China,
推荐引用方式(GB/T 7714)：
Pan Pan,Zhang Qi,Liu Weiyong,et al.Dengue Virus Infection Activates Interleukin-1β to Induce Tissue Injury and Vascular Leakage[J].FRONTIERS IN MICROBIOLOGY.2019,10:doi:10.3389/fmicb.2019.02637.
APA：
Pan, Pan,Zhang, Qi,Liu, Weiyong,Wang, Wenbiao,Yu, Zhenyang...&Wu, Jianguo.(2019).Dengue Virus Infection Activates Interleukin-1β to Induce Tissue Injury and Vascular Leakage.FRONTIERS IN MICROBIOLOGY,10,
MLA：
Pan, Pan,et al."Dengue Virus Infection Activates Interleukin-1β to Induce Tissue Injury and Vascular Leakage".FRONTIERS IN MICROBIOLOGY 10.(2019)
