机构:[1]Second Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou 510115, PR China广东省中医院[2]Postdoctoral Programme, Guangzhou University of Chinese Medicine, Guangzhou 510006, PR China[3]Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510115, PR China广东省中医院[4]Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou 510006, PR China广东省中医院[5]Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, Guangzhou 510115, PR China[6]Key Laboratory for Regenerative Medicine, Ministry of Education, School of Biomedical Sciences, Faculty of Medicine, Chinese University of Hong Kong, 999077, Hong Kong, China[7]Kunming Institute of Zoology, Chinese Academy of Sciences, Chinese University of Hong Kong, Joint Laboratory of Bioresources and Molecular Research of Common Diseases, 999077, Hong Kong, China
Quercetin (QC) is a dietary flavonoid abundant in many natural plants. A series of studies have shown that it has been shown to exhibit several biological properties, including anti-inflammatory, anti-oxidant, cardio-protective, vasodilatory, liver-protective and anti-cancer activities. However, so far the possible therapeutic effect of QC on psoriasis has not been reported. The present study was undertaken to evaluate the potential beneficial effect of QC in psoriasis using a generated imiquimod (IMQ)-induced psoriasis-like mouse model, and to further elucidate its underlying mechanisms of action. Effects of QC on PASI scores, back temperature, histopathological changes, oxidative/anti-oxidative indexes, pro-inflammatory cytokines and NF-kappa B pathway in IMQ-induced mice were investigated. Our results showed that QC could significantly reduce the PASI scores, decrease the temperature of the psoriasis-like lesions, and ameliorate the deteriorating histopathology in IMQ-induced mice. Moreover, QC effectively attenuated levels of TNF-alpha, IL-6 and IL-17 in serum, increased activities of GSH, CAT and SOD, and decreased the accumulation of MDA in skin tissue induced by IMQ in mice. The mechanism may be associated with the down-regulation of NF-kappa B, IKK alpha, NIK and RelB expression and up-regulation of TRAF3, which were critically involved in the non-canonical NF-kappa B pathway. In conclusion, our present study demonstrated that QC had appreciable anti-psoriasis effects in IMQ-induced mice, and the underlying mechanism may involve the improvement of antioxidant and anti-inflammatory status and inhibition on the activation of the NF-kappa B signaling. Hence, QC, a naturally occurring flavone with potent anti-psoriatic effects, has the potential for further development as a candidate for psoriasis treatment.
基金:
the Chinese Medicine Scientific
Research Project of Guangdong Province (No. 20161096), Chinese Medicine
Scientific Research and Technology Research Projects of Chinese Medicine
Hospital of Guangdong Province and the Key Discipline Construction
Projects of Integrative Medicine of High Level University of Guangdong
Province (No. YN2015QN05 & YN2015MS20), Science and Technology
Planning Project of Guangdong Province (No. 2015B020211013), Natural
Science Foundation of Guangdong Province (No. S2013030011515),
Traditional Chinese Medicine Clinical Research Base of China (No.
JDZX2015196) and China Postdoctoral Science Foundation
(2016M600649)
第一作者机构:[1]Second Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou 510115, PR China[2]Postdoctoral Programme, Guangzhou University of Chinese Medicine, Guangzhou 510006, PR China[3]Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510115, PR China[4]Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou 510006, PR China
通讯作者:
通讯机构:[1]Second Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou 510115, PR China[3]Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510115, PR China[4]Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou 510006, PR China[5]Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, Guangzhou 510115, PR China[*1]Second Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou 510115, PR China
推荐引用方式(GB/T 7714):
Chen Haiming,Lu Chuanjian,Liu Huazhen,et al.Quercetin ameliorates imiquimod-induced psoriasis-like skin inflammation in mice via the NF-κB pathway[J].INTERNATIONAL IMMUNOPHARMACOLOGY.2017,48:110-117.doi:10.1016/j.intimp.2017.04.022.
APA:
Chen, Haiming,Lu, Chuanjian,Liu, Huazhen,Wang, Maojie,Zhao, Hui...&Han, Ling.(2017).Quercetin ameliorates imiquimod-induced psoriasis-like skin inflammation in mice via the NF-κB pathway.INTERNATIONAL IMMUNOPHARMACOLOGY,48,
MLA:
Chen, Haiming,et al."Quercetin ameliorates imiquimod-induced psoriasis-like skin inflammation in mice via the NF-κB pathway".INTERNATIONAL IMMUNOPHARMACOLOGY 48.(2017):110-117