机构：[a]The 2nd Clinical Medical College (Shenzhen People’s Hospital) of Jinan University, No. 1017, Dongmen North Road, Luohu District, Shenzhen 518020, Guangdong,China深圳市人民医院深圳医学信息中心[b]Integrated Chinese and Western Medicine Postdoctoral Research Station, Jinan University, No. 601, Huangpu Road West, Guangzhou 510632, Guangdong, China[c]Formula-Pattern Research Center, School of Traditional Chinese Medicine, Jinan University, No. 601, Huangpu Road West, Guangzhou 510632, Guangdong, China[d]School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, No.11, East Road of Third North Ring, Chaoyang District, Beijing 100029, China
Diabetic nephropathy (DN) is a chronic kidney disease caused by the long-term loss of renal function, which occurs in 20% - 40% of all diabetes and is also the primary cause of end-stage renal diseases. DN is related with other lethal diseases, particularly cardiovascular diseases, leading to an increased risk of death. Therefore, an effective treatment for DN is required. Here we tested the protective effect of dioscin in a mouse model of streptozocin (STZ)-induced DN. First, STZ was intraperitoneally injected into C57BL/6 J mice and TLR4(-/-) mice respectively, on a daily basis for 5 days to induce diabetes. Dioscin was then orally administered into diabetic mice daily for 8 weeks. Our results show that STZ injection effectively induced diabetes in mice as indicated by the increased blood glucose levels in C57BL/6 J mice, whereas it did not cause diabetes in TLR4 / mice. Dioscin significantly ameliorated STZ-induced renal damage via reducing inflammatory responses in diabetic mice and antagonizing the activation of TLR4/NF-kappa B pathway and the production of inflammatory cytokines. In conclusion, our study highlights the potential of dioscin as a novel approach to treat DN in diabetic patients.
基金：
China Postdoctoral Science Foundation [2019M663400]
第一作者机构：[a]The 2nd Clinical Medical College (Shenzhen People’s Hospital) of Jinan University, No. 1017, Dongmen North Road, Luohu District, Shenzhen 518020, Guangdong,China[b]Integrated Chinese and Western Medicine Postdoctoral Research Station, Jinan University, No. 601, Huangpu Road West, Guangzhou 510632, Guangdong, China
通讯作者：
通讯机构：[a]The 2nd Clinical Medical College (Shenzhen People’s Hospital) of Jinan University, No. 1017, Dongmen North Road, Luohu District, Shenzhen 518020, Guangdong,China[c]Formula-Pattern Research Center, School of Traditional Chinese Medicine, Jinan University, No. 601, Huangpu Road West, Guangzhou 510632, Guangdong, China[d]School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, No.11, East Road of Third North Ring, Chaoyang District, Beijing 100029, China[*1]The 2nd Clinical Medical College (Shenzhen People's Hospital) of Jinan University, No. 1017, Dongmen North Road, Luohu District, Shenzhen 518020, Guangdong, China.
推荐引用方式(GB/T 7714)：
Cai Shengyu,Chen Jiaxu,Li Yousheng.Dioscin protects against diabetic nephropathy by inhibiting renal inflammation through TLR4/NF-kappa B pathway in mice[J].IMMUNOBIOLOGY.2020,225(3):doi:10.1016/j.imbio.2020.151941.
APA：
Cai, Shengyu,Chen, Jiaxu&Li, Yousheng.(2020).Dioscin protects against diabetic nephropathy by inhibiting renal inflammation through TLR4/NF-kappa B pathway in mice.IMMUNOBIOLOGY,225,(3)
MLA：
Cai, Shengyu,et al."Dioscin protects against diabetic nephropathy by inhibiting renal inflammation through TLR4/NF-kappa B pathway in mice".IMMUNOBIOLOGY 225..3(2020)
