机构：[1]Department of Clinical Laboratory, The Third Affiliated Hospital, Sun Yat‑Sen University,Guangzhou, Guangdong 510630中山大学附属第三医院[2]Department of Clinical Laboratory, The Second Affiliated Hospital,Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510120[3]Department ofInfectious Diseases, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou,Guangdong 510150[4]Department of Infectious Diseases,The Third Affiliated Hospital, Sun Yat‑Sen University, Guangzhou, Guangdong 510630, P.R. China中山大学附属第三医院[5]Vaccine Research Institute,The Third Affiliated Hospital, Sun Yat‑Sen University, Guangzhou, Guangdong 510630, P.R. China中山大学附属第三医院
Hepatic stellate cell (HSC) activation is important in the pathogenesis of liver fibrosis. However, the molecular mechanism of HSC activation is not completely understood. In the present study, it was demonstrated that interleukin-32 gamma (IL-32 gamma) is capable of enhancing intefgrin alpha v beta 6 expression by inducing integrin alpha v beta 6 promoter activity in a dose-dependent manner in HSCs. Furthermore, it was determined that nuclear factor kappa B (NF-kappa B)activation is required for IL-32 gamma-induced integrin alpha v beta 6 expression. Increased integrin alpha v beta 6 expression is then able to activate HSCs. These results indicate that NF-kappa B activation is required for IL-32 gamma to induce integrin alpha v beta 6 expression and consequently promote HSC activation. Therefore, IL-32 gamma activates HSCs and therefore may be associated with hepatic fibrogenesis. These results may enable the development of novel effective strategies to treat hepatic fibrosis.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81401306, 81401191, 81102531]
第一作者机构：[1]Department of Clinical Laboratory, The Third Affiliated Hospital, Sun Yat‑Sen University,Guangzhou, Guangdong 510630[2]Department of Clinical Laboratory, The Second Affiliated Hospital,Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510120
共同第一作者：
通讯作者：
通讯机构：[4]Department of Infectious Diseases,The Third Affiliated Hospital, Sun Yat‑Sen University, Guangzhou, Guangdong 510630, P.R. China[5]Vaccine Research Institute,The Third Affiliated Hospital, Sun Yat‑Sen University, Guangzhou, Guangdong 510630, P.R. China[*1]Department of Infectious Diseases, The Third Affiliated Hospital, Sun Yat‑Sen University, 600 Tianhe Road, Guangzhou, Guangdong 510630, P.R. China[*2]Vaccine Research Institute, The Third Affiliated Hospital, Sun Yat‑Sen University, 600 Tianhe Road, Guangzhou, Guangdong 510630, P.R. China
推荐引用方式(GB/T 7714)：
Liu Hongcan,Pan Xingfei,Cao Hong,et al.IL-32 gamma promotes integrin alpha v beta 6 expression through the activation of NF-kappa B in HSCs[J].EXPERIMENTAL AND THERAPEUTIC MEDICINE.2017,14(4):3880-3886.doi:10.3892/etm.2017.4956.
APA：
Liu, Hongcan,Pan, Xingfei,Cao, Hong,Shu, Xin,Sun, Haixia...&Zhang, Qi.(2017).IL-32 gamma promotes integrin alpha v beta 6 expression through the activation of NF-kappa B in HSCs.EXPERIMENTAL AND THERAPEUTIC MEDICINE,14,(4)
MLA：
Liu, Hongcan,et al."IL-32 gamma promotes integrin alpha v beta 6 expression through the activation of NF-kappa B in HSCs".EXPERIMENTAL AND THERAPEUTIC MEDICINE 14..4(2017):3880-3886
