Effect of folic acid supplementation on risk of new-onset diabetes in adults with hypertension in China: Findings from the China Stroke Primary Prevention Trial (CSPPT)
机构：[1]National Clinical Research Center for Kidney Disease, State Key Laboratory for Organ Failure Research, Renal Division, Nanfang Hospital,Southern Medical University[2]Department of Cardiology, Peking University First Hospital[3]Department of Epidemiology and Biostatistics,School of Public Health, Peking University Health Science Center, Beijing[4]Department of Neurology, First People’s Hospital, Lianyungang[5]Department of Neurology, First Affiliated Hospital of Anhui Medical University[6]Institute for Biomedicine,Anhui Medical University, Hefei, China[7]School of Health Administration,Anhui Medical University, Hefei, China[8]Department of Neurology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou广东省中医院[9]Department of Population, Family and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland,USA
BackgroundThe aim of the present post hoc analysis of the China Stroke Primary Prevention Trial (CSPPT) was to evaluate the effect of folic acid supplementation on the risk of new-onset diabetes in hypertensive adults in China. MethodsIn all, 20 702 hypertensive adults with no history of stroke and/or myocardial infarction (MI) were randomly assigned to receive double-blind daily treatment with tablets containing either: (i) 10 mg enalapril and 0.8 mg folic acid (n = 10 348); or (ii) 10 mg enalapril alone (n = 10 354). New-onset diabetes was defined as either self-reported physician-diagnosed diabetes or the use of glucose-lowering drugs during the follow-up period of the CSPPT. ResultsOver a median treatment duration of 4.5 years, new-onset diabetes occurred in 198 (2.0%) and 214 (2.1%) subjects in the enalapril-folic acid and enalapril groups, respectively (hazard ratio [HR] 0.92; 95% confidence interval [CI] 0.76-1.12). Similar results were observed when analyses were limited to subjects with baseline fasting glucose (FG) <7.0 mmol/L (HR 0.85; 95% CI 0.62-1.14). Furthermore, there was no significant group difference in: (i) the risk of new-onset FG 7.0 mmol/L (defined as FG <7.0 at baseline and 7.0 mmol/L at the last visit; relative risk [RR] 1.07; 95% CI 0.96-1.20); or (ii) the composite of new-onset diabetes or new-onset FG 7.0 mmol/L (RR = 1.06; 95% CI 0.95-1.19). ConclusionsAmong adults with hypertension with no history of stroke and/or MI in China, folic acid supplementation had no significant effect on the risk of new-onset diabetes.
基金：
Shenzhen AUSA Pharmed (Shenzhen, China); Major State Basic Research Development Program of China (973 program)National Basic Research Program of China [2102 CB517703]; National Science and Technology Major Projects Specialized for "Major New Drugs Innovation and Development" during the 12th Five-year Plan Period: China Stroke Primary Prevention Trial, a Clinical Center grant [zx09101105, zx09401013]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81473052, 81441091, 81402735]; National Clinical Research Center for Kidney Disease, Nanfang Hospital, Nanfang Medical University, Guangzhou, China; State Key Laboratory for Organ Failure Research, Nanfang Hospital; Department of Development and Reform, Shenzhen Municipal Government [SFG 20201744]
第一作者机构：[1]National Clinical Research Center for Kidney Disease, State Key Laboratory for Organ Failure Research, Renal Division, Nanfang Hospital,Southern Medical University
通讯作者：
通讯机构：[2]Department of Cardiology, Peking University First Hospital[*1]Department of Cardiology, Peking University First Hospital, No. 8 Xishiku Street, Xicheng District, Beijing 100034, China.
推荐引用方式(GB/T 7714)：
Qin Xianhui,Li Jianping,Zhang Yan,et al.Effect of folic acid supplementation on risk of new-onset diabetes in adults with hypertension in China: Findings from the China Stroke Primary Prevention Trial (CSPPT)[J].JOURNAL OF DIABETES.2016,8(2):286-294.doi:10.1111/1753-0407.12346.
APA：
Qin, Xianhui,Li, Jianping,Zhang, Yan,Chen, Dafang,Wang, Binyan...&Huo, Yong.(2016).Effect of folic acid supplementation on risk of new-onset diabetes in adults with hypertension in China: Findings from the China Stroke Primary Prevention Trial (CSPPT).JOURNAL OF DIABETES,8,(2)
MLA：
Qin, Xianhui,et al."Effect of folic acid supplementation on risk of new-onset diabetes in adults with hypertension in China: Findings from the China Stroke Primary Prevention Trial (CSPPT)".JOURNAL OF DIABETES 8..2(2016):286-294
