CD11c antigen presenting cells with high B7-H4 expression in active tuberculosis patients are associated with low stimulatory capacity to T cell proliferation
机构：[1]Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, No. 1 Xincheng Road, Dongguan523808, Guangdong, China[2]Department of Respiration, Dongguan 6th Hospital, Dongguan 523008, Guangdong,China[3]Department of Clinical Immunology, Institute of Laboratory Medicine, Guangdong Medical College,No. 1 Xincheng Road, Dongguan 523808, Guangdong, China[4]Department of Laboratory Medicine, GuangdongProvincial Hospital of Traditional Chinese Medicine, Guangzhou 510120, Guangdong, China[5]Department ofMicrobiology and Immunology, Center for Primate Biomedical Research, University of Illinois College of Medicine,Chicago, Illinois, USA[6]Department of Medicine, University of Maryland School of Medicine, Baltimore 21201,MD, USA.
B7-H4 is a co-inhibitory molecule that negatively regulates T lymphocytes, playing a role in immune suppression many disorders. However, the role of antigen presenting cells (APCs)-expressing B7-H4 in active pulmonary tuberculosis (ATB) remains poorly understood. Here, we demonstrated that B7-H4 expression on CD11c APCs increased in patients with ATB. B7-H4 expression on CD11c APCs was associated with high expression of HLA-DR and CD86 both in healthy controls (HCs) and in ATB patients. However, CD86 expression in B7-H4-expressing CD11c APCs was significantly lower in ATB patients compared to that in HCs. Importantly, B7-H4 expressing CD11c APCs from ATB patients showed a lower stimulatory capacity to T cell proliferation than those from HCs in mixed leukocyte culture test. Collectively, our data suggest that the evaluation of B7-H4 expression in CD11c APCs in patients with active tuberculosis might be one of the key molecular mechanisms for the dysfunction of APCs in TB patients. B7-H4 may have important implications in the prevention and treatment of patients with ATB.
基金：
National Natural Science
Foundation of China (81273237, 81570009),
Natural Science Foundation of Guangdong
Province (2015A030313513), the Key Project
of Science and Technology Innovation of
Education Department of Guangdong Province
(2012KJCX0059), the Science and Technology
Project of Dongguan (2012105102016,
2014108101018) and the Science and Technology Innovation Fund of Guangdong Medical
College (STIF201110, B2012078).
第一作者机构：[1]Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, No. 1 Xincheng Road, Dongguan523808, Guangdong, China[5]Department ofMicrobiology and Immunology, Center for Primate Biomedical Research, University of Illinois College of Medicine,Chicago, Illinois, USA
通讯作者：
通讯机构：[1]Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, No. 1 Xincheng Road, Dongguan523808, Guangdong, China[3]Department of Clinical Immunology, Institute of Laboratory Medicine, Guangdong Medical College,No. 1 Xincheng Road, Dongguan 523808, Guangdong, China[*1]Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, No. 1 Xincheng Road.Department of Clinical Immunology, Institute of Laboratory Medicine, Guangdong Medical College, No. 1 Xincheng Road, Dongguan 523808, Guangdong, China
推荐引用方式(GB/T 7714)：
Wang Wan-Dang,Liu Gan-Bin,Zhang Jun-Ai,et al.CD11c antigen presenting cells with high B7-H4 expression in active tuberculosis patients are associated with low stimulatory capacity to T cell proliferation[J].INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE.2016,9(3):7008-+.
APA：
Wang, Wan-Dang,Liu, Gan-Bin,Zhang, Jun-Ai,Lu, Yuan-Bin,Gao, Yu-Chi...&Xu, Jun-Fa.(2016).CD11c antigen presenting cells with high B7-H4 expression in active tuberculosis patients are associated with low stimulatory capacity to T cell proliferation.INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE,9,(3)
MLA：
Wang, Wan-Dang,et al."CD11c antigen presenting cells with high B7-H4 expression in active tuberculosis patients are associated with low stimulatory capacity to T cell proliferation".INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE 9..3(2016):7008-+
