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CD11C antigen presenting cells with high B7-H4 expression in active tuberculosis patients are associated with low stimulatory capacity to T cell proliferation

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作者：
Wan-Dang Wang[1,5] * ; Gan-Bin Liu[2] * ; Jun-Ai Zhang[1,3] * ; Yuan-Bin Lu[1,3] ; Yu-Chi Gao[1,3] ; You-Chao Dai[1,3] ; Shi-Yan Yu[1,3] ; Yan Jia[1,3] ; Xiao-Xia Fu[1] ; Zhi Chen[1] ; Feng Qiu[4] ; Lai-Long Yi[2] ; Zheng W Chen[5] ; Jixin Zhong[6] ; Jun-Fa Xu[1,3,*1] ;
机构： [1]Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, No. 1 Xincheng Road, Dongguan 523808, Guangdong, China [2]Department of Respiration, Dongguan 6th Hospital, Dongguan 523008, Guangdong, China [3]Department of Clinical Immunology, Institute of Laboratory Medicine, Guangdong Medical College, No. 1 Xincheng Road, Dongguan 523808, Guangdong, China [4]Department of Laboratory Medicine, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou 510120, Guangdong, China [5]Department of Microbiology and Immunology, Center for Primate Biomedical Research, University of Illinois College of Medicine, Chicago, Illinois, USA [6]Department of Medicine, University of Maryland School of Medicine, Baltimore 21201, MD, USA.
出处：
ISSN：

关键词： B7-H4 CD11c APCs Stimulatory capacity T cell proliferation

摘要：
B7-H4 is a co-inhibitory molecule that negatively regulates T lymphocytes, playing a role in immune suppression many disorders. However, the role of antigen presenting cells (APCs)-expressing B7-H4 in active pulmonary tuberculosis (ATB) remains poorly understood. Here, we demonstrated that B7-H4 expression on CD11c APCs increased in patients with ATB. B7-H4 expression on CD11c APCs was associated with high expression of HLA-DR and CD86 both in healthy controls (HCs) and in ATB patients. However, CD86 expression in B7-H4-expressing CD11c APCs was significantly lower in ATB patients compared to that in HCs. Importantly, B7-H4 expressing CD11c APCs from ATB patients showed a lower stimulatory capacity to T cell proliferation than those from HCs in mixed leukocyte culture test. Collectively, our data suggest that the evaluation of B7-H4 expression in CD11c APCs in patients with active tuberculosis might be one of the key molecular mechanisms for the dysfunction of APCs in TB patients. B7-H4 may have important implications in the prevention and treatment of patients with ATB. © 2016, E-Century Publishing Corporation. All rights reserved.

基金：
This work was supported by the National Natural Science Foundation of China (81273237, 81570009), Natural Science Foundation of Guangdong Province (2015A030313513), the Key Project of Science and Technology Innovation of Education Department of Guangdong Province (2012KJCX0059), the Science and Technology Project of Dongguan (2012105102016, 2014108101018) and the Science and Technology Innovation Fund of Guangdong Medical College (STIF201110, B2012078).
语种：
外文
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出版当年[2015]版：
大类 | 4 区 医学
小类 | 4 区 医学：研究与实验
最新[2025]版：
大类 | 4 区 医学
小类 | 4 区 医学：研究与实验
第一作者：
第一作者机构： [1]Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, No. 1 Xincheng Road, Dongguan 523808, Guangdong, China [5]Department of Microbiology and Immunology, Center for Primate Biomedical Research, University of Illinois College of Medicine, Chicago, Illinois, USA
共同第一作者：
通讯作者：
通讯机构： [1]Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, No. 1 Xincheng Road, Dongguan 523808, Guangdong, China [3]Department of Clinical Immunology, Institute of Laboratory Medicine, Guangdong Medical College, No. 1 Xincheng Road, Dongguan 523808, Guangdong, China [*1]Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, No. 1 Xincheng Road, Department of Clinical Immunology, Institute of Laboratory Medicine, Guangdong Medical College, No. 1 Xincheng Road, Dongguan 523808, Guangdong, China.
推荐引用方式(GB/T 7714)：
Wan-Dang Wang,Gan-Bin Liu,Jun-Ai Zhang,et al.CD11C antigen presenting cells with high B7-H4 expression in active tuberculosis patients are associated with low stimulatory capacity to T cell proliferation[J].International Journal of Clinical and Experimental Medicine.2016,9(3):
APA：
Wan-Dang Wang,Gan-Bin Liu,Jun-Ai Zhang,Yuan-Bin Lu,Yu-Chi Gao...&Jun-Fa Xu.(2016).CD11C antigen presenting cells with high B7-H4 expression in active tuberculosis patients are associated with low stimulatory capacity to T cell proliferation.International Journal of Clinical and Experimental Medicine,9,(3)
MLA：
Wan-Dang Wang,et al."CD11C antigen presenting cells with high B7-H4 expression in active tuberculosis patients are associated with low stimulatory capacity to T cell proliferation".International Journal of Clinical and Experimental Medicine 9..3(2016)

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