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miR-200b is a key regulator of tumor progression and metabolism targeting lactate dehydrogenase A in human malignant glioma

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收录情况： ◇ SCIE

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机构： [1]Department of Neurosurgery, Cancer Center of Guangzhou Medical University, Guangzhou, Guangdong, 510095, China [2]State Key Laboratory of Respiratory Disease, The 1st Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, 510120, China [3]Department of Physiology, School of Basic Science, Guangzhou Medical University, Guangzhou, Guangdong, 510182, China [4]Guangdong Provincial Hospital of TCM Breast Department, Guangzhou, Guangdong, 510006, China

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关键词： glioma miR-200b LDHA proliferation metabolism

摘要：

Lactate dehydrogenase A (LDHA) is involved in various cancers. In this study, we investigated the expression and function of LDHA in glioma. We found that LDHA was up-regulated in glioma samples. Furthermore, we found that overexpression of LDHA promoted proliferation, invasion and glycolysis in glioma cells. Luciferase reporter assays confirmed that LDHA was a direct target of miR-200b. miR-200b was found to be down-regulated in glioma samples, which was inversely correlated with LDHA expression. Repression of LDHA by miR-200b suppressed the glycolysis, cell proliferation and invasion of glioma cells. These results provide evidence that miR-200b acts as a tumor suppressor in glioma through the inhibition of LDHA both in vitro and in vivo. Targeting LDHA through miR-200b could be a potential therapeutic strategy in glioma.

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出版当年[2015]版：

大类 | 1 区

医学

小类 | 2 区肿瘤学 3 区细胞生物学

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无

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出版当年[2014]版：

Q1 ONCOLOGY Q1 CELL BIOLOGY

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无

影响因子： 0 最新[2023版] 0 最新五年平均 6.359 出版当年[2014版] 6.368 出版当年五年平均 6.627 出版前一年[2013版] 5.008 出版后一年[2015版]

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第一作者机构： [1]Department of Neurosurgery, Cancer Center of Guangzhou Medical University, Guangzhou, Guangdong, 510095, China

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