机构：[1]Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, 510515, PR China[2]Department of Pharmacology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, 510515, PR China[3]Cancer Center, TCM-Integrated Hospital, Southern Medical University Guangzhou, Guangdong, 510515, PR China
Gliomas are the most common form of malignant primary brain tumors with poor 5-year survival rate. Dysregulation of procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 (PLOD2) was observed in gliomas, but the specific role and molecular mechanism of PLOD2 in glioma have not been reported yet. In this study, PLOD2 was found to be frequently up-regulated in glioma and could serve as an independent prognostic marker to identify patients with poor clinical outcome. Knockdown of PLOD2 inhibited proliferation, migration and invasion of glioma cells in vitro and in vivo. Mechanistically, inhibition of PLOD2 inactivated PI3K/AKT signaling pathway and thus regulated the expression of its downstream epithelial-mesenchymal transition (EMT)-associated regulators, including E-cadherin, vimentin, N-cadherin, β-catenin, snail and slug in glioma cells. Moreover, PLOD2 could be induced by hypoxia-inducible factor-1α (HIF-1α) via hypoxia, thereby promoting hypoxia-induced EMT in glioma cells. Our data suggests that PLOD2 may be a potential therapeutic target for patients with glioma.
基金：
This study was supported by National Nature Science Fund of China (NO.81372692, 81502178, 81502177) (http://www.nsfc.gov.cn), Natural Science Fund of Guangdong Province, China (NO. 2014A030313303, 2014A030313282, 2016A030313549) (http://www.gdstc. gov.cn), Science and Technology Program of Guangzhou, China (NO. 201607010350) (http://wsbs.gzsi.gov.cn/login. html), President Fund of Nanfang Hospital (2013Z008, 2014B007) (http://www.nfyy.com), The funders had no role in study design, data collection, data analysis, decision to publish, or preparation of the manuscript.
语种：
外文
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中科院(CAS)分区：
出版当年[2016]版：
大类|1 区医学
小类|2 区细胞生物学2 区肿瘤学
最新[2025]版：
无
第一作者：
第一作者机构：[1]Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, 510515, PR China
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推荐引用方式(GB/T 7714)：
Ye Song,Shihao Zheng,Jizhou Wang,et al.Hypoxia-induced PLOD2 promotes proliferation, migration and invasion via PI3K/Akt signaling in glioma.[J].Oncotarget.2017,8(26):41947-41962.doi:10.18632/oncotarget.16710.
APA：
Ye Song,Shihao Zheng,Jizhou Wang,Hao Long,Luxiong Fang...&Songtao Qi.(2017).Hypoxia-induced PLOD2 promotes proliferation, migration and invasion via PI3K/Akt signaling in glioma..Oncotarget,8,(26)
MLA：
Ye Song,et al."Hypoxia-induced PLOD2 promotes proliferation, migration and invasion via PI3K/Akt signaling in glioma.".Oncotarget 8..26(2017):41947-41962
医学