机构：[1]Traditional and Complementary Medicine Research Program, School of Health Sciences and Health Innovations Research Institute (HIRi), RMIT University, Bundoora, Victoria, Australia[2]Guangdong Provincial Hospital of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, and The Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou, China广东省中医院
Chronic cough is a significant health burden. Patients experience variable benefits from over the counter and prescribed products, but there is an unmet need to provide more effective treatments. Natural products have been used to treat cough and some plant compounds such as pseudoephedrine from ephedra and codeine from opium poppy have been developed into drugs. Text mining historical literature may offer new insight for future therapeutic development. We identified natural products used in the East Asian historical literature to treat chronic cough. Evaluation of the historical literature revealed 331 natural products used to treat chronic cough. Products included plants, minerals and animal substances. These natural products were found in 75 different books published between AD 363 and 1911. Of the 331 products, the 10 most frequently and continually used products were examined, taking into consideration findings from contemporary experimental studies. The natural products identified are promising and offer new directions in therapeutic development for treating chronic cough.
基金：
China-Australia International Research Centre for Chinese Medicine (CAIRCCM) - a joint initiative of RMIT University, Australia; Guangdong Provincial Academy of Chinese Medical Sciences, China
第一作者机构：[1]Traditional and Complementary Medicine Research Program, School of Health Sciences and Health Innovations Research Institute (HIRi), RMIT University, Bundoora, Victoria, Australia
通讯作者：
通讯机构：[2]Guangdong Provincial Hospital of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, and The Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou, China[*1]Guangdong Provincial Hospital of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou 510120, China
推荐引用方式(GB/T 7714)：
Shergis Johannah Linda,Wu Lei,May Brian H.,et al.Natural products for chronic cough: Text mining the East Asian historical literature for future therapeutics[J].CHRONIC RESPIRATORY DISEASE.2015,12(3):204-211.doi:10.1177/1479972315583043.
APA：
Shergis, Johannah Linda,Wu, Lei,May, Brian H.,Zhang, Anthony Lin,Guo, Xinfeng...&Xue, Charlie Changli.(2015).Natural products for chronic cough: Text mining the East Asian historical literature for future therapeutics.CHRONIC RESPIRATORY DISEASE,12,(3)
MLA：
Shergis, Johannah Linda,et al."Natural products for chronic cough: Text mining the East Asian historical literature for future therapeutics".CHRONIC RESPIRATORY DISEASE 12..3(2015):204-211
