机构：[1]Department of Mammary Disease, Guangdong Provincial Hospital of Chinese Medicine, The Second Clinical Collage of Guangzhou University of Chinese Medicine, Guangzhou, China大德路总院乳腺科大德路总院乳腺科广东省中医院[2]Department of Breast Oncology, Sun Yat-sen Univeristy Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, China[3]Pharmacy College, State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Guangzhou, China
Caveolin-1 (Cav-1) is both a tumor suppressor and an oncoprotein. Cav-1 overexpression was frequently confirmed in advanced cancer stages and positively associated with ABC transporters, cancer stem cell populations, aerobic glycolysis activity and autophagy. Cav-1 was tied to various stresses including radiotherapy, fluid shear and oxidative stresses and ultraviolet exposure, and interacted with stress signals such as AMP-activated protein kinase. Finally, a Cav-1 fluctuation model during cancer development is provided and Cav-1 is suggested to be a stress signal and cytoprotective. Loss of Cav-1 may increase susceptibility to oncogenic events. However, research to explore the underlying molecular network between Cav-1 and stress signals is warranted.
基金：
National Natural science Foundation of China (81402173) and Pearl River S&T Nova Program of Guangzhou (201506010098).
第一作者机构：[1]Department of Mammary Disease, Guangdong Provincial Hospital of Chinese Medicine, The Second Clinical Collage of Guangzhou University of Chinese Medicine, Guangzhou, China
通讯作者：
推荐引用方式(GB/T 7714)：
Wang Zhiyu,Wang Neng,Liu Pengxi,et al.Caveolin-1, a stress-related oncotarget, in drug resistance[J].ONCOTARGET.2015,6(35):37135-37150.doi:10.18632/oncotarget.5789.
APA：
Wang, Zhiyu,Wang, Neng,Liu, Pengxi,Peng, Fu,Tang, Hailin...&Situ, Honglin.(2015).Caveolin-1, a stress-related oncotarget, in drug resistance.ONCOTARGET,6,(35)
MLA：
Wang, Zhiyu,et al."Caveolin-1, a stress-related oncotarget, in drug resistance".ONCOTARGET 6..35(2015):37135-37150
