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The Role of Exosomal microRNA in Cancer Drug Resistance.

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机构： [1]Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China, [2]Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Medical University, Haikou, China, [3]Guangzhou Institute of Pediatrics/Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, China, [4]School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China, [5]Collaborative Innovation Center for Cancer, Institute of Respiratory and Occupational Diseases, Medical College, Shanxi Datong University, Datong, China, [6]Research Centre for Applied Science and Technology, Tribhuvan University, Kirtipur, Nepal, [7]Key Laboratory of Emergency and Trauma of Ministry of Education, School of Tropical Medicine and Laboratory Medicine, Hainan Medical University, Haikou, China

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关键词： exosome miRNA cancer drug resistance mechanism

摘要：

Exosomes affect the initiation and progression of cancers. In the tumor microenvironment, not only cancer cells, but also fibroblasts and immunocytes secrete exosomes. Exosomes act as a communicator between cells by transferring different cargos and microRNAs (miRNAs). Drug resistance is one of the critical factors affecting therapeutic effect in the course of cancer treatment. The currently known mechanisms of drug resistance include drug efflux, alterations in drug metabolism, DNA damage repair, alterations of energy programming, cancer stem cells and epigenetic changes. Many studies have shown that miRNA carried by exosomes is closely associated with the development of drug resistance mediated by the above-mentioned mechanisms. This review article will discuss how exosomal miRNAs regulate the drug resistance. Copyright © 2020 Guo, Wang, Yan, Liu, Su, Chen, Yan, Adhikari, Wu and Zhang.

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出版当年[2019]版：

大类 | 2 区医学

小类 | 3 区肿瘤学

最新[2025]版：

大类 | 3 区医学

小类 | 4 区肿瘤学

第一作者：

第一作者机构： [1]Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China, [2]Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Medical University, Haikou, China,

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通讯机构： [1]Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China, [2]Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Medical University, Haikou, China, [7]Key Laboratory of Emergency and Trauma of Ministry of Education, School of Tropical Medicine and Laboratory Medicine, Hainan Medical University, Haikou, China

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