Honokiol Suppresses Renal Cancer Cells' Metastasis via Dual-Blocking Epithelial-Mesenchymal Transition and Cancer Stem Cell Properties through Modulating miR-141/ZEB2 Signaling
机构：[1]Department of Medical Oncology, Affiliated Cancer Hospital of Guangzhou Medical University, Cancer Center of Guangzhou Medical University (CCGMU),[2]The Medical Faculty of Jinan University,[3]Department of Neurology, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine,广东省中医院[4]Internal Medicine of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, People’s Republic of China,深圳市中医院深圳医学信息中心
Renal cell carcinoma (RCC) is associated with a high frequency of metastasis and only few therapies substantially prolong survival. Honokiol, isolated from Magnolia spp. bark, has been shown to exhibit pleiotropic anticancer effects in many cancer types. However, whether honokiol could suppress RCC metastasis has not been fully elucidated. In the present study, we found that honokiol suppressed renal cancer cells' metastasis via dual-blocking epithelial-mesenchymal transition (EMT) and cancer stem cell (CSC) properties. In addition, honokiol inhibited tumor growth in vivo. It was found that honokiol could up-regulate miR-141, which targeted ZEB2 and modulated ZEB2 expression. Honokiol reversed EMT and suppressed CSC properties partly through the miR-141/ZEB2 axis. Our study suggested that honokiol may be a suitable therapeutic strategy for RCC treatment.
基金：
This work was supported by Research Project of Guangzhou
Medical University (2013C61).
第一作者机构：[1]Department of Medical Oncology, Affiliated Cancer Hospital of Guangzhou Medical University, Cancer Center of Guangzhou Medical University (CCGMU),
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通讯作者：
推荐引用方式(GB/T 7714)：
Weidong Li,Qian Wang,Qiaozhen Su,et al.Honokiol Suppresses Renal Cancer Cells' Metastasis via Dual-Blocking Epithelial-Mesenchymal Transition and Cancer Stem Cell Properties through Modulating miR-141/ZEB2 Signaling[J].MOLECULES AND CELLS.2014,37(5):383-388.doi:10.14348/molcells.2014.0009.
APA：
Weidong Li,Qian Wang,Qiaozhen Su,Dandan Ma,Chang An...&Hongfeng Liang.(2014).Honokiol Suppresses Renal Cancer Cells' Metastasis via Dual-Blocking Epithelial-Mesenchymal Transition and Cancer Stem Cell Properties through Modulating miR-141/ZEB2 Signaling.MOLECULES AND CELLS,37,(5)
MLA：
Weidong Li,et al."Honokiol Suppresses Renal Cancer Cells' Metastasis via Dual-Blocking Epithelial-Mesenchymal Transition and Cancer Stem Cell Properties through Modulating miR-141/ZEB2 Signaling".MOLECULES AND CELLS 37..5(2014):383-388
