机构：[1]Department of Pharmacy, Shenzhen Hospital of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong 518000广州中医药大学深圳医院深圳市康宁医院深圳医学信息中心[2]Department of Big Data Research of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, Guangdong 510120大德路总院科研广东省中医院[3]Department of Pediatrics, the Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006[4]Formula Pattern Research Center, School of Traditional Chinese Medicine, Jinan University, Guangzhou, Guangdong 510632[5]Department of Oncology, Shenzhen Hospital of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong 518000, P.R. China广州中医药大学深圳医院深圳市康宁医院深圳医学信息中心
Epithelial‑mesenchymal transition (EMT), during which cancer cells lose the epithelial phenotype and gain the mesenchymal phenotype, has been verified to result in tumor migration and invasion. Numerous studies have shown that dysregulation of the Wnt/β‑catenin signaling pathway gives rise to EMT, which is characterized by nuclear translocation of β‑catenin and E‑cadherin suppression. Wnt/β‑catenin signaling was confirmed to be affected by microRNAs (miRNAs), several of which are down‑ or upregulated in metastatic cancer cells, indicating their complex roles in Wnt/β‑catenin signaling. In this review, we demonstrated the targets of various miRNAs in altering Wnt/β‑catenin signaling to promote or inhibit EMT, which may elucidate the underlying mechanism of EMT regulation by miRNAs and provide evidence for potential therapeutic targets in the treatment of invasive tumors.
基金：
This review was supported by the National Natural Science
Foundation of China (grant nos. 81803790, 81573918, and
81703975), National Natural Science Foundation of Guangdong
(grant no. 2020A1515011090), Project of Administration of
Traditional Chinese Medicine of Guangdong Province of
China (grant no. 20181069), the Fundamental Research Funds
for the Central Universities (grant no. 21618336), and Public
Health Research Projects of Futian District, Shenzhen (grant
no. FTWS2019064)
第一作者机构：[1]Department of Pharmacy, Shenzhen Hospital of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong 518000
共同第一作者：
通讯作者：
通讯机构：[4]Formula Pattern Research Center, School of Traditional Chinese Medicine, Jinan University, Guangzhou, Guangdong 510632[5]Department of Oncology, Shenzhen Hospital of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong 518000, P.R. China[*1]Department of Oncology, Shenzhen Hospital of Guangzhou University of Chinese Medicine, 6001 Beihuan Avenue, Shenzhen, Guangdong 518000, P.R. China[*2]Formula Pattern Research Center, School of Traditional Chinese Medicine, Jinan University, 605 Huangpu Avenue West, Guangzhou, Guangdong 510632, P.R. China
推荐引用方式(GB/T 7714)：
YUHE LEI,LEI CHEN,GE ZHANG,et al.MicroRNAs target the Wnt/β-catenin signaling pathway to regulate epithelial-mesenchymal transition in cancer[J].ONCOLOGY REPORTS.2020,44(4):1299-1313.doi:10.3892/or.2020.7703.
APA：
YUHE LEI,LEI CHEN,GE ZHANG,AIYUN SHAN,CHUNFENG YE...&LIJUAN DENG.(2020).MicroRNAs target the Wnt/β-catenin signaling pathway to regulate epithelial-mesenchymal transition in cancer.ONCOLOGY REPORTS,44,(4)
MLA：
YUHE LEI,et al."MicroRNAs target the Wnt/β-catenin signaling pathway to regulate epithelial-mesenchymal transition in cancer".ONCOLOGY REPORTS 44..4(2020):1299-1313
