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The Pseudomonas aeruginosa Mannose Sensitive Hamemagglutination Strain (PA-MSHA) Induces a Th1-Polarizing Phenotype by Promoting Human Dendritic Cells Maturation

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机构: [1]Department of Stomatology, Guangzhou Women and Children’s Medical Center, Guangzhou, China [2]Department of Laboratory Medicine, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China [3]Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
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关键词: PA-MSHA strain Differentiation of Th cell Dendritic cells Immunomodulatory capacity

摘要:
Pseudomonas aeruginosa mannose sensitive hamemagglutination strain (PA-MSHA) is a kind of peritrichous P. aeruginosa strain with MSHA fimbriae and has been shown to activate kinds of immunocytes. Dendritic cells (DCs) are specialized antigen-presenting cells required for the stimulating and priming CD4(+) T cells toward the T helper cell type 1 (Th1), Th2 and other different phenotypes. PA-MSHA effecting on Th1 remains an important missing link. Here we demonstrated that PA-MSHA augmented monocytes derived-dendritic cells (Mo-DCs) expression of HLA-DR, co-stimulatory and adhesion molecules, and induced Th1-promoting interleukin-12 and tumor necrosis factor alpha secretion, in addition, PA-MSHA treated Mo-DCs displayed lesser endocytic capacity. Furthermore, in mixed lymphocyte reactions, allostimulatory capacity of Mo-DCs was enhanced by PA-MSHA, CD4(+) T cells stimulated by PA-MSHA -activated Mo-DCs showed a Th1-polarized cytokine production, increasing secretion of IFN-gamma and decreasing secretion of IL-10 and IL-4. Our findings identified PA-MSHA as an important exogenous factor that induced DCs maturation toward a Th1-promoting phenotype.

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出版当年[2013]版:
大类 | 4 区 生物
小类 | 4 区 生物工程与应用微生物 4 区 微生物学
最新[2025]版:
大类 | 4 区 生物学
小类 | 4 区 生物工程与应用微生物 4 区 微生物学
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出版当年[2012]版:
Q4 MICROBIOLOGY Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
最新[2024]版:
Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Q4 MICROBIOLOGY

影响因子: 最新[2024版] 最新五年平均 出版当年[2012版] 出版当年五年平均 出版前一年[2011版] 出版后一年[2013版]

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第一作者机构: [1]Department of Stomatology, Guangzhou Women and Children’s Medical Center, Guangzhou, China
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