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Human memory T cell responses to SARS-CoV E protein

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收录情况： ◇ SCIE

作者：
Peng, H[a] * ; Yang, L.-t[a] ; Li, J[b] ; Lu, Z.-q[c] ; Wang, L.-y[d] ; Koup, R.A[e] ; Bailer, R.T[e] ; Wu, C.-y[a] ;
机构： [a]Department of Immunology, Zhongshan Medical School, Sun Yat-sen University, No. 74 Zhongshan Road II, Guangzhou 510089, China [b]Department of Cardiology, Guangdong Provincial Hospital of Traditional Chinese Medicine, No. 111 Dade Road, Guangzhou 510020, China [c]Department of Respiratory Disease, the Second Affıliated Hospital of Sun Yat-sen University, No. 107 Yanjiang Road, Guangzhou 510020, China [d]Department of Digestive Diseases, the Second Affıliated Hospital of Sun Yat-sen University, No. 107 Yanjiang Road, Guangzhou 510020, China [e]Vaccine Research Center, NIAID/NIH, Bethesda, MD 20892, USA
出处：
DOI： 10.1016/j.micinf.2006.05.008
ISSN：

关键词： E protein Epitope Human Memory T cells SARS coronavirus

摘要：
E protein is a membrane component of severe acute respiratory syndrome coronavirus (SARS-CoV). Disruption of E protein may reduce viral infectivity. Thus, the SARS-CoV E protein is considered a potential target for the development of antiviral drugs. However, the cellular immune responses to E protein remain unclear in humans. In this study, we found that peripheral blood mononuclear cells (PBMCs) from fully recovered SARS individuals rapidly produced IFN-γ and IL-2 following stimulation with a pool of 9 peptides overlapping the entire E protein sequence. Analysis of the immune responses by flow cytometry showed that both CD4+ and CD8+T cells were involved in the SARS-CoV E-specific immune responses after stimulation with SARS-CoV E peptides. Moreover, the majority of IFN-γ+CD4+T cells were central memory cells expressing CD45RO+CCR7+CD62L-; whereas IFN-γ+CD8+ memory T cells were mostly effector memory cells expressing CD45RO-CCR7-CD62L-. The results of T-cell responses to 9 individual peptides indicated that the E protein contained at least two major T cell epitopes (E2 amino acid [aa] 9-26 and E5-6: aa 33-57) which were important in eliciting cellular immune response to SARS-CoV E protein in humans. © 2006 Elsevier SAS. All rights reserved.

基金：
This study was supported by grants from National Nature Science Foundation of China (No. 30340012); Scientific Technology Program of Guangdong (No. 2003Z3-E0491); Ministry of Education, Guangdong Province of China and the National Key Basic Research Program of China (No. 2001CB510007). We thank the individuals who donated their blood for this study. We also thank Z. Peng for performing flow cytometry assays.
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外文
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WOS：
中科院(CAS)分区：
出版当年[2005]版：
大类 | 2 区 医学
最新[2025]版：
大类 | 4 区 医学
小类 | 4 区 免疫学 4 区 传染病学 4 区 微生物学
JCR分区：
出版当年[2004]版：
Q1 VIROLOGY Q1 IMMUNOLOGY Q1 MICROBIOLOGY
最新[2023]版：
Q3 IMMUNOLOGY Q3 INFECTIOUS DISEASES Q3 MICROBIOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2004版] 出版当年五年平均 出版前一年[2003版] 出版后一年[2005版]

第一作者：
第一作者机构： [a]Department of Immunology, Zhongshan Medical School, Sun Yat-sen University, No. 74 Zhongshan Road II, Guangzhou 510089, China
通讯作者：
推荐引用方式(GB/T 7714)：
Peng H,Yang L.-t,Li J,et al.Human memory T cell responses to SARS-CoV E protein[J].MICROBES AND INFECTION.2006,8(9-10):2424-2431.doi:10.1016/j.micinf.2006.05.008.
APA：
Peng, H,Yang, L.-t,Li, J,Lu, Z.-q,Wang, L.-y...&Wu, C.-y.(2006).Human memory T cell responses to SARS-CoV E protein.MICROBES AND INFECTION,8,(9-10)
MLA：
Peng, H,et al."Human memory T cell responses to SARS-CoV E protein".MICROBES AND INFECTION 8..9-10(2006):2424-2431

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