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Long non-coding RNA mortal obligate RNA transcript inhibits the migration and invasion of colon cancer cells by inactivating transforming growth factor β1.

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收录情况： ◇ SCIE

作者：
Zhou Taicheng[1] * ; Wu Lili[2] * ; Zong Zhen[3] * ; Ma Ning[1] ; Li Yingru[1] ; Jiang Zhipeng[1] ; Wang Qirui[4,*1] ; Chen Shuang[1,*2] ;
机构： [1]Department of Gastroenterological Surgery and Hernia Center, The Sixth Affiliated Hospital of Sun Yat‑Sen University,Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Disease, Guangzhou, Guangdong 510655 [2]Department of Ultrasonology, The Third Affiliated Hospital of Sun Yat‑Sen University, Guangzhou, Guangdong 510630 [3]Department of Gastroenterological Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang,Jiangxi 510655 [4]Department of Molecular Biology, State Administration of Traditional Chinese Medicine ofthe People's Republic of China, School of Traditional Chinese Medicine, Southern Medical University,Guangzhou, Guangdong 510515, P.R. China
出处：
DOI： 10.3892/ol.2019.11189
ISSN：

关键词： colon cancer long non‑coding RNA mortal obligate RNA transcript transforming growth factor β1 prognosis

摘要：
Long non-coding (lnc)RNA mortal obligate RNA transcript (MORT) is inhibited in numerous types of cancer in humans, indicating its role as a tumor suppressor. The present study demonstrated downregulation of lncRNA MORT in the tumor tissues of patients with colon cancer. The expression of MORT in tumor tissues was linearly associated with its expression levels in plasma. Low MORT expression was associated with low overall survival rate. Moreover, the overexpression of MORT resulted in decreased, whereas treatment with transforming growth factor β1 (TGF-β1) resulted in increased, invasion and migration rates of colon cancer cells. In addition, TGF-β1 treatment attenuated the inhibitory effect of MORT overexpression on the invasion and migration rates of colon cancer cells. The overexpression of MORT inhibited TGF-β1 expression in colon cancer cells, whereas treatment with TGF-β1 failed to affect the expression of the lncRNA. Therefore, it is postulated that MORT inhibits invasion and migration colon cancer cells by inactivating TGF-β1. Copyright: © Zhou et al.

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外文
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中科院(CAS)分区：
出版当年[2019]版：
大类 | 4 区 医学
小类 | 4 区 肿瘤学
最新[2025]版：
大类 | 4 区 医学
小类 | 4 区 肿瘤学
JCR分区：
出版当年[2018]版：
Q4 ONCOLOGY
最新[2023]版：
Q3 ONCOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2018版] 出版当年五年平均 出版前一年[2017版] 出版后一年[2019版]

第一作者：
第一作者机构： [1]Department of Gastroenterological Surgery and Hernia Center, The Sixth Affiliated Hospital of Sun Yat‑Sen University,Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Disease, Guangzhou, Guangdong 510655
共同第一作者：
通讯作者：
通讯机构： [1]Department of Gastroenterological Surgery and Hernia Center, The Sixth Affiliated Hospital of Sun Yat‑Sen University,Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Disease, Guangzhou, Guangdong 510655 [4]Department of Molecular Biology, State Administration of Traditional Chinese Medicine ofthe People's Republic of China, School of Traditional Chinese Medicine, Southern Medical University,Guangzhou, Guangdong 510515, P.R. China [*1]Department of Molecular Biology, State Administration of Traditional Chinese Medicine of the People's Republic of China, School of Traditional Chinese Medicine, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou, Guangdong 510515, P.R. China [*2]Department of Gastroenterological Surgery and Hernia Center, The Sixth Affiliated Hospital of Sun Yat‑Sen University, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Disease, 26 Yuancun Erheng Road, Tianhe, Guangzhou, Guangdong 510655, P.R. China
推荐引用方式(GB/T 7714)：
Zhou Taicheng,Wu Lili,Zong Zhen,et al.Long non-coding RNA mortal obligate RNA transcript inhibits the migration and invasion of colon cancer cells by inactivating transforming growth factor β1.[J].ONCOLOGY LETTERS.2020,19(2):1131-1136.doi:10.3892/ol.2019.11189.
APA：
Zhou Taicheng,Wu Lili,Zong Zhen,Ma Ning,Li Yingru...&Chen Shuang.(2020).Long non-coding RNA mortal obligate RNA transcript inhibits the migration and invasion of colon cancer cells by inactivating transforming growth factor β1..ONCOLOGY LETTERS,19,(2)
MLA：
Zhou Taicheng,et al."Long non-coding RNA mortal obligate RNA transcript inhibits the migration and invasion of colon cancer cells by inactivating transforming growth factor β1.".ONCOLOGY LETTERS 19..2(2020):1131-1136

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