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Effect of neuromedin U on allergic airway inflammation in an asthma model.

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机构： [1]Guangzhou University of Chinese Medicine,Guangzhou, Guangdong 510405, P.R. China [2]Department of Anaesthesiology,The First Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou, Guangdong 510405, P.R. China

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关键词： allergy asthma type 2 innate lymphoid cells neuromedin U mast cells eosinophils neuroimmunity

摘要：

Asthma is a major inflammatory airway disease with high incidence and mortality rates. The Global Initiative for Asthma released a report called 'The Global Burden of Asthma' in 2004. However, the specific pathogenesis of asthma remains unclear. An increasing number of studies have demonstrated that neuromedin U (NMU) plays a pleiotropic role in the pathogenesis of asthma. NMU is a highly structurally conserved neuropeptide that was first purified from porcine spinal cord and named for its contractile effect on the rat uterus. NMU amplifies type 2 innate lymphoid cell (ILC2)-driven allergic lung inflammation. The NMU receptors (NMURs), designated as NMUR1 and NMUR2, belong to the G protein-coupled receptor family. NMUR1 has also been found in immune cells, including ILC2s, mast cells and eosinophils. In view of the important roles of NMU in the pathogenesis of asthma, the present review evaluates the potential mechanisms underlying the impact of NMU on asthma and its association with asthma therapy. Copyright: © Ren et al.

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出版当年[2019]版：

大类 | 4 区医学

小类 | 4 区医学：研究与实验

最新[2025]版：

大类 | 4 区医学

小类 | 4 区医学：研究与实验

第一作者：

第一作者机构： [1]Guangzhou University of Chinese Medicine,Guangzhou, Guangdong 510405, P.R. China [2]Department of Anaesthesiology,The First Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou, Guangdong 510405, P.R. China

通讯作者：

通讯机构： [1]Guangzhou University of Chinese Medicine,Guangzhou, Guangdong 510405, P.R. China [2]Department of Anaesthesiology,The First Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou, Guangdong 510405, P.R. China [*1]Department of Anaesthesiology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, 12 Jichang Road, Guangzhou, Guangdong 510405, P.R. China

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