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RNA N6-methyladenosine: a promising molecular target in metabolic diseases.

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机构: [1]Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, 610072 Sichuan China. [2]Houjie Hospital of Dongguan, Dongguan, 523945 Guangdong China. [3]Chengdu Tumor Hospital, Chengdu, 610041 Sichuan China. [4]Hangzhou Xixi Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, 310023 Zhejiang China.
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关键词: N6-methyladenosine Methylation Methyltransferase Demethylase Adipogenesis Metabolic diseases

摘要:
N6-methyladenosine is a prevalent and abundant transcriptome modification, and its methylation regulates the various aspects of RNAs, including transcription, translation, processing and metabolism. The methylation of N6-methyladenosine is highly associated with numerous cellular processes, which plays important roles in the development of physiological process and diseases. The high prevalence of metabolic diseases poses a serious threat to human health, but its pathological mechanisms remain poorly understood. Recent studies have reported that the progression of metabolic diseases is closely related to the expression of RNA N6-methyladenosine modification. In this review, we aim to summarize the biological and clinical significance of RNA N6-methyladenosine modification in metabolic diseases, including obesity, type 2 diabetes, non-alcoholic fatty liver disease, hypertension, cardiovascular diseases, osteoporosis and immune-related metabolic diseases. © The Author(s) 2020.

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出版当年[2019]版:
大类 | 3 区 生物
小类 | 3 区 生化与分子生物学
最新[2025]版:
大类 | 2 区 生物学
小类 | 2 区 生化与分子生物学
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第一作者机构: [1]Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, 610072 Sichuan China.
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