机构：[1]Shenzhen Baoan Traditional Chinese Medicine Hospital Group, Shenzhen, People’s Republic of China[2]Department of Pharmacy, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, People’s Republic of China[3]Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, People’s Republic of China[4]Key Laboratory for Major Obstetric Diseases of Guangdong Province, Guangzhou Medical University, Guangzhou, People’s Republic of China
Ganoderma lucidum (G. lucidum) is a famous medicinal fungus used as a traditional medicine for generations in China. Among bioactivities that G. lucidum possesses, the anti-tumor effect has aroused extensive interests. In this study, one new triterpene (1) was isolated from 90% ethanol extract of the dried fruiting bodies of G. lucidum. Its structure was determined based on the analysis of its spectroscopic data, including 1 D and 2 D NMR and MS spectra. Furthermore, 1 elicited moderate anti-tumor activities (IC50 values of 15.38 ± 0.34 and 18.61 ± 0.55 μM for A549 and HepG2 cells, respectively) compared with cisplatin which was employed as the positive drug with IC50 values of 8.21 ± 0.17 and 5.36 ± 0.29 μM for A549 and HepG2 cells, respectively. The mechanism study by RT-qPCR and western blot analysis suggested that the p53/caspase-3 pathway is involved in the 1-induced apoptosis.
基金：
Administration of Traditional Chinese Medicine of
Guangdong Province [grant number 20211341] , National Natural Science Foundation of China
[grant number 81803689], the Natural Science Foundation of Guangdong Province [grant number
2018A030310292], and the YIWEN Talent Project of The Third Affiliated Hospital of
Guangzhou Medical University [grant number 2021#9].
第一作者机构：[1]Shenzhen Baoan Traditional Chinese Medicine Hospital Group, Shenzhen, People’s Republic of China
共同第一作者：
通讯作者：
通讯机构：[2]Department of Pharmacy, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, People’s Republic of China[4]Key Laboratory for Major Obstetric Diseases of Guangdong Province, Guangzhou Medical University, Guangzhou, People’s Republic of China[*1]The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, No. 63, Duobao Road
推荐引用方式(GB/T 7714)：
Cao Liping,Jin Hongliu,Liang Qi,et al.A new anti-tumor cytotoxic triterpene from Ganoderma lucidum.[J].NATURAL PRODUCT RESEARCH.2022,36(16):4125-4131.doi:10.1080/14786419.2021.1976175.
APA：
Cao Liping,Jin Hongliu,Liang Qi,Yang Haiyi,Li Shuguang...&Yuan Zhongwen.(2022).A new anti-tumor cytotoxic triterpene from Ganoderma lucidum..NATURAL PRODUCT RESEARCH,36,(16)
MLA：
Cao Liping,et al."A new anti-tumor cytotoxic triterpene from Ganoderma lucidum.".NATURAL PRODUCT RESEARCH 36..16(2022):4125-4131
