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The effect of ketogenic diet on behaviors and synaptic functions of naive mice.

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机构: [1]Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, School of Basic Medical Sciences, Institute of Neuroscience and Department of Neurology of the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China [2]Department of Physiology, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, China [3]South China Research Center for Acupuncture and Moxibustion, Medical College of Acu‐Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, China [4]Department of Clinical Nutrition, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China [5]Guangdong Province Key Laboratory of Psychiatric Disorders, Guangzhou, China
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关键词: ketogenic diet naive mice behaviors synaptic plasticity

摘要:
Beyond its application as an epilepsy therapy, the ketogenic diet (KD) has been considered a potential treatment for a variety of other neurological and metabolic disorders. However, whether KD promotes functional restoration by reducing the pathological processes underlying individual diseases or through some independent mechanisms is not clear. In this study, we evaluated the effect of KD on a series of behaviors and synaptic functions of young adult naive mice. Wild-type C57BL/6J mice at age of 2-3 months were fed with control diet or KD for three months. Body weight and caloric intake were monitored throughout the experiments. We assessed behavioral performance with seizure induction, motor coordination and activity, anxiety level, spatial learning and memory, sociability, and depression. Synaptic transmission and long-term potentiation were also recorded. KD-fed mice performed equivalent to control-diet-fed mice in the behavioral tests and electrophysiological assays except exhibiting slower weight gain and increased seizure threshold. Our results contribute to the better understanding of effects of the KD on physiological behaviors and synaptic functions. © 2019 The Authors. Brain and Behavior published by Wiley Periodicals, Inc.

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出版当年[2018]版:
大类 | 4 区 医学
小类 | 4 区 行为科学 4 区 神经科学
最新[2025]版:
大类 | 3 区 心理学
小类 | 3 区 行为科学 4 区 神经科学
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出版当年[2017]版:
Q3 BEHAVIORAL SCIENCES Q3 NEUROSCIENCES
最新[2023]版:
Q2 BEHAVIORAL SCIENCES Q3 NEUROSCIENCES

影响因子: 最新[2023版] 最新五年平均 出版当年[2017版] 出版当年五年平均 出版前一年[2016版] 出版后一年[2018版]

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第一作者机构: [1]Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, School of Basic Medical Sciences, Institute of Neuroscience and Department of Neurology of the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China
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通讯机构: [1]Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, School of Basic Medical Sciences, Institute of Neuroscience and Department of Neurology of the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China [4]Department of Clinical Nutrition, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China [5]Guangdong Province Key Laboratory of Psychiatric Disorders, Guangzhou, China [*1]Department of Clinical Nutrition, the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China. [*2]Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, School of Basic Medical Sciences, Institute of Neuroscience and Department of Neurology of the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
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