详情页 - 广东省中医院知识库

当前位置：首页 > 详情页

p53 induces miR-199a-3p to suppress mechanistic target of rapamycin activation in cisplatin-induced acute kidney injury.

文献详情

资源类型：

Pubmed体系：

作者：

机构： [1]Department of Nephrology, The Affiliated Jiangmen TCM Hospital of Jinan University, Jiangmen, Guangdong, P. R. China [2]Department of Nephrology, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, P. R. China [3]Department of Acupuncture Moxibustion and Massage, Hunan University of Chinese Medicine, Changsha, Hunan, P.R. China

出处：

DOI：

ISSN：

关键词： acute kidney injury cisplatin miR‐199a‐3p mechanistic target of rapamycin p53

摘要：

How p53 participates in acute kidney injury (AKI) progress and what are the underlying mechanisms remain illusive. For this issue, it is important to probe into the role of p53 in cisplatin-induced AKI. We find that p53 was upregulated in cisplatin-induced AKI, yet, pifithrin-α inhibites the p53 expression to attenuated renal injury and cell apoptosis both in vivo cisplatin-induced AKI mice and in vitro HK-2 human renal tubular epithelial cells. To knock down p53 by siRNA significantly decreased the miRNA, miR-199a-3p, expression in HK-2 cells. Blockade of miR-199a-3p significantly reduced cisplatin-induced cell apoptosis and inhibited caspase-3 activity. Mechanistically, we identified that miR-199a-3p directly bound to mechanistic target of rapamycin (mTOR) 3'-untranslated region and overexpressed miR-199a-3p reduce the expression and phosphorylation of mTOR. Furthermore, we demonstrated that p53 inhibited mTOR activation through activating miR-199a-3p. In conclusion, our findings reveal that p53, upregulating the expression of miR-199a-3p affects the progress of cisplatin-induced AKI, which might provide a promising therapeutic target of AKI. © 2019 Wiley Periodicals, Inc.

语种：

PubmedID：

中科院(CAS)分区：

出版当年[2018]版：

大类 | 3 区生物

小类 | 3 区生化与分子生物学 4 区细胞生物学

最新[2025]版：

大类 | 3 区生物学

小类 | 4 区生化与分子生物学 4 区细胞生物学

第一作者：

第一作者机构： [1]Department of Nephrology, The Affiliated Jiangmen TCM Hospital of Jinan University, Jiangmen, Guangdong, P. R. China

通讯作者：

通讯机构： [1]Department of Nephrology, The Affiliated Jiangmen TCM Hospital of Jinan University, Jiangmen, Guangdong, P. R. China [*1]Department of Nephrology, The Affiliated Jiangmen TCM Hospital of Jinan University, No. 30 Huayuan East Road, 529000 Jiangmen, Guangdong, P. R. China.

推荐引用方式(GB/T 7714)：

APA：

MLA：

相关文献

[1]Shenshuaifu Granule Attenuates Acute Kidney Injury by Inhibiting Ferroptosis Mediated by p53/ SLC7A11/GPX4 Pathway [2]檀香提取物调控miR-199a-3p对大鼠心肌细胞缺氧/复氧损伤的作用 [3]JianPiYiShen formula prevents cisplatin-induced acute kidney injury in mice by improving necroptosis through MAPK pathway [4]Huangqi-Danshen decoction protects against cisplatin-induced acute kidney injury in mice [5]Xihuang pills induce apoptosis in hepatocellular carcinoma by suppressing phosphoinositide 3-kinase/protein kinase-B/mechanistic target of rapamycin pathway. [6]QUERCETIN ALLEVIATES CISPLATIN-INDUCED ACUTE KIDNEY INJURY BY REBALANCING TGF-BETA/SMAD SIGNALLING [7]The effect of monotropein on alleviating cisplatin-induced acute kidney injury by inhibiting oxidative damage, inflammation and apoptosis. [8]Untargeted Metabolomics Reveals the Protective Effect of a Traditional Chinese Herbal Decoction on Cisplatin-Induced Acute Kidney Injury. [9]A Chinese Medicine Compound Alleviates Cisplatin-Induced Acute Kidney Injury via Its Antiapoptosis and Anti-Inflammation Effects in Mice [10]Artesunate-Nanoliposome-TPP, a Novel Drug Delivery System That Targets the Mitochondria, Attenuates Cisplatin-Induced Acute Kidney Injury by Suppressing Oxidative Stress and Inflammatory Effects