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Anticancer activity of polysaccharide from Glehnia littoralis on human lung cancer cell line A549.

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资源类型：
Pubmed体系：
作者：
Jun Wu[a,c,*1] * ; Weiping Gao[b] * ; Zhuoyue Song[a] * ; Qingping Xiong[e] ; Yingtao Xu[c] ; Yun Han[d] ; Jun Yuan[e] ; Rong Zhang[a] ; Yunbo Cheng[a] ; Jiansong Fang[a] ; Weirong Li[a] ; Qi Wang[a,*1] ;
机构： [a]Guangzhou University of Chinese Medicine, Guangzhou, 510006, Guangdong, PR China [b]Affiliated Huai’an Hospital of Xuzhou Medical University, Huai’an, 223001, Jiangsu, PR China [c]School of Chinese Medicine, Shandong College of Traditional Chinese Medicine, Yantai, 264199, Shangdong, PR China [d]School of Integrated Chinese and Western Medicine, Binzhou Medical University, Yantai, 264003, Shangdong, PR China [e]Key Laboratory for Medicinal Exploitation and Utilization of Characteristic Resources, and College of Chemical Engineering, Huaiyin Institute ofTechnology, Huai’an, 223003, Jiangsu, PR China
出处：
DOI： 10.1016/j.ijbiomac.2017.08.033
ISSN：

关键词： Polysaccharide Glehnia littoralis Lung cancer

摘要：
The purpose of this study was to investigate the anticancer activity of polysaccharide (PGL) from Glehnia littoralis on human lung cancer cell line A549. Based on MTT assay, the results suggested that PGL could significantly reduce A549 cells proliferation in a time- and dose-dependent manner. In addition, PGL displayed an inhibitory activity for the A549 cells migration in Transwell migration assay. The results from both flow cytometry analysis and Hochst 3342 staining of apoptotic cells indicated that PGL could promote apoptosis, and induce cycle arrest of A549 cells. Moreover, immunofluorescence assay elucidated PGL could also down-regulate expression of proliferating cell nuclear antigen (PCNA). Overall, these results showed that PGL exerts a strong anticancer action through inhibiting the A549 cells migration, proliferation and inducing cell apoptosis. It could be a new source of natural anticancer agent against lung cancer with potential value in supplements and medicine. Copyright © 2017 Elsevier B.V. All rights reserved.

基金：
This work was partly supported by the Chinese PostdoctoralScience Foundation (No. 2017M612642) and Natural Science Foun-dation of Shandong Province (No. ZR2016HB20).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类 | 3 区 生物
小类 | 2 区 应用化学 2 区 高分子科学 3 区 生化与分子生物学
最新[2025]版：
大类 | 2 区 生物学
小类 | 2 区 生化与分子生物学 2 区 应用化学 2 区 高分子科学
第一作者：
第一作者机构： [a]Guangzhou University of Chinese Medicine, Guangzhou, 510006, Guangdong, PR China [c]School of Chinese Medicine, Shandong College of Traditional Chinese Medicine, Yantai, 264199, Shangdong, PR China [*1]Guangzhou University of Chinese Medicine,Guangzhou, 510006, Guangdong, PR China.
共同第一作者：
通讯作者：
通讯机构： [a]Guangzhou University of Chinese Medicine, Guangzhou, 510006, Guangdong, PR China [c]School of Chinese Medicine, Shandong College of Traditional Chinese Medicine, Yantai, 264199, Shangdong, PR China [*1]Guangzhou University of Chinese Medicine,Guangzhou, 510006, Guangdong, PR China.
推荐引用方式(GB/T 7714)：
Jun Wu,Weiping Gao,Zhuoyue Song,et al.Anticancer activity of polysaccharide from Glehnia littoralis on human lung cancer cell line A549.[J].International journal of biological macromolecules.2018,106:464-472.doi:10.1016/j.ijbiomac.2017.08.033.
APA：
Jun Wu,Weiping Gao,Zhuoyue Song,Qingping Xiong,Yingtao Xu...&Qi Wang.(2018).Anticancer activity of polysaccharide from Glehnia littoralis on human lung cancer cell line A549..International journal of biological macromolecules,106,
MLA：
Jun Wu,et al."Anticancer activity of polysaccharide from Glehnia littoralis on human lung cancer cell line A549.".International journal of biological macromolecules 106.(2018):464-472

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