机构：[1]Department of Oncology and Cancer Biotherapy Center, Zhejiang Provincial People’s Hospital, Hangzhou, Zhejiang 310014, China[2]Zhejiang Academy of Traditional Chinese Medicine, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang 310012, China[3]Department of Biochemistry, Guangzhou University of Chinese Medicine, Guangzhou 510006, China[4]State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-Sen University, Guangzhou 510060, Guangdong, China
Curcumin is potentially therapeutic for malignant diseases. The mechanisms of this effect might involve a combination of antioxidant, immunomodulatory, proapoptotic, and antiangiogenic activities. However, the exact mechanisms are not fully understood. In the present study, we provided evidences that curcumin suppressed the expression of enhancer of zeste homolog 2 (EZH2) in lung cancer cells both transcriptionally and post-transcriptionally. Curcumin inhibited the expression of EZH2 through microRNA (miR)-let 7c and miR-101. Curcumin decreased the expression of NOTCH1 through the inhibition of EZH2. There was a reciprocal regulation between EZH2 and NOTCH1 in lung cancer cells. These observations suggest that curcumin inhibits lung cancer growth and metastasis at least partly through the inhibition of EZH2 and NOTCH1.
基金：
This work was supported by the Natural Science Foundation of China (81172385/H1618 to G-Q.W.), the Science Technology Department of Zhejiang Province (2012C13015-1 to G-Q.W.), the Natural Science Foundation of Zhejiang Province (Y2090961 to G-Q.W.), and the Health Bureau of Zhejiang Province (2010QNA003 to G-Q.W., 2011ZDA003 to K-Q.C., 2012RCA004 to A-H.Z., 2012RCB002 to Q.X., and 2016ZA030 to Y.C.).
第一作者机构：[1]Department of Oncology and Cancer Biotherapy Center, Zhejiang Provincial People’s Hospital, Hangzhou, Zhejiang 310014, China
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通讯作者：
推荐引用方式(GB/T 7714)：
Guo-Qing Wu,Ke-Qun Chai,Xiu-Ming Zhu,et al.Anti-cancer effects of curcumin on lung cancer through the inhibition of EZH2 and NOTCH1.[J].ONCOTARGET.2016,7(18):26535-26550.doi:10.18632/oncotarget.8532.
APA：
Guo-Qing Wu,Ke-Qun Chai,Xiu-Ming Zhu,Hua Jiang,Xiao Wang...&Dong-Sheng Huang.(2016).Anti-cancer effects of curcumin on lung cancer through the inhibition of EZH2 and NOTCH1..ONCOTARGET,7,(18)
MLA：
Guo-Qing Wu,et al."Anti-cancer effects of curcumin on lung cancer through the inhibition of EZH2 and NOTCH1.".ONCOTARGET 7..18(2016):26535-26550
医学