机构：[1]Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics,Institute of Laboratory Medicine, Guangdong Medical University, Dongguan523808, China[2]Department of Gynaecology and Obstetrics, HuizhouHospital of Traditional Chinese Medicine, Huizhou 516000, China
Circular RNAs are a new class of endogenous non-coding RNA that can function as crucial regulators of diverse cellular processes. The diverse types of circular RNAs with varying cytogenetics in cancer have also been reported. Circular RNAs can act as a microRNA sponge or through other mechanisms to regulate gene expression as either tumor inhibitors or accelerators, suggesting that circular RNAs can serve as newly developed biomarkers with clinic implications. Here, we summerized recent advances on circular RNAs in cancer and described a circular RNA network associated with tumorigenesis. The clinical implications of circular RNAs in cancer were also discussed in this paper.
Growing evidence has revealed the crucial regulatory roles of circular RNAs in cancer and the elucidation of functional mechanisms involving circular RNAs would be helpful to construct a circRNA-miRNA-mRNA regulatory network. Moreover, circular RNAs can be easily detected due to their relative stability, widespread expression, and abundance in exosomes, blood and saliva; thus, circular RNAs have potential as new and ideal clinical biomarkers in cancer.
基金：
This work was supported by the National Natural Science Foundation of China
(81300398), the Natural Science Foundation of Guangdong Province
(2015A030313528), the 2013 Sail Plan “Introduction of the Shortage of Top-Notch
Talent” Project (YueRenCaiBan [2014] 1) and the Project of Administration of
Traditional Chinese Medicine of Guangdong Province (20141277, 20162079).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类|3 区医学
小类|3 区肿瘤学
最新[2025]版：
大类|3 区医学
小类|3 区肿瘤学
第一作者：
第一作者机构：[1]Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics,Institute of Laboratory Medicine, Guangdong Medical University, Dongguan523808, China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Zhang Zikang,Xie Qing,He Dongmei,et al.Circular RNA: new star, new hope in cancer.[J].BMC cancer.2018,18(1):834.doi:10.1186/s12885-018-4689-7.
APA：
Zhang Zikang,Xie Qing,He Dongmei,Ling Yuan,Li Yuchao...&Zhang Hua.(2018).Circular RNA: new star, new hope in cancer..BMC cancer,18,(1)
MLA：
Zhang Zikang,et al."Circular RNA: new star, new hope in cancer.".BMC cancer 18..1(2018):834
