MicroRNA‑214 suppresses propofol‑induced neuroapoptosis through activation of phosphoinositide 3‑kinase/protein kinase B signaling by targeting phosphatase and tensin homolog expression.
机构：[1]Departments of Anesthesiology,The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong 515041, P.R. China[2]Departments of Traditional Chinese Medicine, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong 515041, P.R. China
The present study aimed to investigate the effects of microRNA (miR)‑214 on neuroapoptosis induced by propofol and the possible mechanism of its anti‑apoptotic effects. Initially, it was observed that miR‑214 expression was upregulated in propofol‑induced neuroapoptosis rats. Next, propofol‑treated nerve cells were transfected with miR‑214 mimics. The results revealed that miR‑214 overexpression induced apoptosis, inhibited cell proliferation, inhibited cyclin D1 protein expression, promoted caspase‑3 activity and B‑cell lymphoma 2‑associated X protein expression, and enhanced the levels of inflammation factors in nerve cells treated with propofol. In addition, miR‑214 overexpression suppressed phosphoinositide 3‑kinase/protein kinase B (PI3K/Akt) signaling by targeting the activation of phosphatase and tensin homolog (PTEN) and nuclear factor‑κB expression in nerve cells treated with propofol. Treatment with a PTEN inhibitor successfully suppressed the PTEN protein expression and decreased the apoptosis of propofol‑treated nerve cells subsequent to miR‑214 overexpression through PI3K/Akt signaling. In conclusion, the present study data revealed that miR‑214 suppressed propofol‑induced neuroapoptosis through the activation of PI3K/Akt signaling by targeting PTEN expression.
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外文
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出版当年[2017]版：
大类|3 区医学
小类|4 区医学：研究与实验
最新[2025]版：
大类|2 区医学
小类|2 区医学：研究与实验
第一作者：
第一作者机构：[1]Departments of Anesthesiology,The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong 515041, P.R. China
通讯作者：
通讯机构：[2]Departments of Traditional Chinese Medicine, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong 515041, P.R. China[*1]Department of Traditional Chinese Medicine, The First Affiliated Hospital of Shantou University Medical College, 57 Changping Road, Shantou, Guangdong 515041, P.R. China
推荐引用方式(GB/T 7714)：
XUKENG GUO,MINGHUA CHENG,WEIQI KE,et al.MicroRNA‑214 suppresses propofol‑induced neuroapoptosis through activation of phosphoinositide 3‑kinase/protein kinase B signaling by targeting phosphatase and tensin homolog expression.[J].International journal of molecular medicine.2018,42(5):2527-2537.doi:10.3892/ijmm.2018.3814.
APA：
XUKENG GUO,MINGHUA CHENG,WEIQI KE,YUTING WANG&XUAN JI.(2018).MicroRNA‑214 suppresses propofol‑induced neuroapoptosis through activation of phosphoinositide 3‑kinase/protein kinase B signaling by targeting phosphatase and tensin homolog expression..International journal of molecular medicine,42,(5)
MLA：
XUKENG GUO,et al."MicroRNA‑214 suppresses propofol‑induced neuroapoptosis through activation of phosphoinositide 3‑kinase/protein kinase B signaling by targeting phosphatase and tensin homolog expression.".International journal of molecular medicine 42..5(2018):2527-2537
