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Prevention of platelet aggregation and arterial thrombosis using a modified Shenzhu Guanxin Formula

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WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Huang, M[1] * ; Wu, H[1,2] ; Wu, J[1] ; Chen, Q[1] ; Zou, D[3] ; Xu, D[1,4,*1] ;
机构： [1]Department of Cardiology, The Second AffiliatedHospital of Guangzhou University of Chinese Medicine,Guangzhou, Guangdong, P.R. China [2]Dongzhimen Hospital, Beijing University of ChineseMedicine, Beijing, P.R. China [3]Emergency Department, The First Affiliated Hospital ofSun Yat-sen University, Guangzhou, Guangdong, P.R. China [4]Postdoctoral Research Center, Fujian University ofTraditional Chinese Medicine, Fujian, P.R. China
出处：
DOI： 10.1177/0300060520941326
ISSN：

关键词： adenosine 5′-diphosphate arterial thrombosis cyclic adenosine monophosphate modified Shenzhu Guanxin formula phosphoinositide 3-kinase/protein kinase B signaling Platelet aggregation

摘要：
Objective: Modified Shenzhu Guanxin Formula (mSGF) has beneficial effects in coronary artery disease. Previously, we found that mSGF inhibited platelet aggregation in rats. In the present study we further investigated the antiplatelet and antithrombotic activities of mSGF in rats. Methods: Rats were orally administered mSGF (4.2, 8.4, or 16.8 g crude drug/kg), the adenosine 5′-diphosphate (ADP) receptor antagonist clopidogrel (7.875 mg/kg), or saline once a day for 7 days. The effects of mSGF on platelet aggregation were measured. Levels of cyclic adenosine monophosphate (cAMP) and phosphoinositide 3-kinase (PI3K) signaling were analyzed by ELISA and western blotting, respectively. The antithrombotic effect of mSGF was investigated using a FeCl3-induced carotid arterial thrombosis model and effects on bleeding time were assessed in a rat tail transection model. Results: mSGF significantly inhibited ADP-induced platelet aggregation in a dose-dependent manner, elevated cAMP levels and inhibited phosphorylation of extracellular signal-regulated kinase (ERK) and PI3K/protein kinase B (Akt). Moreover, mSGF dose-dependently inhibited thrombosis in a FeCl3-induced carotid arterial thrombus model and had a significantly smaller effect on bleeding time compared with clopidogrel. Conclusions: mSGF represents a potent and safe antithrombotic agent whose antiplatelet activity is probably mediated through blockade of PI3K/Akt signaling and increased cAMP generation. © The Author(s) 2020.

基金：
This work was supported by the Guangzhou Science and Technology Plan project (No. 201710010107), the Natural Science Foundation of China (Nos. 81403341 and 81774219), the Guangdong Provincial Science and Technology Plan (No. 2016A020226011), the Joint Innovation Specific Project in Key Areas from the Guangdong Branch Institute of the China Academy of Chinese Medical Sciences (No. ZZ0908065) and the Clinical Research of Lingnan Academic Schools of TCM from Guangdong Provincial Hospital of Chinese Medicine (No. YN2014LN07).
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2019]版：
大类 | 4 区 医学
小类 | 4 区 医学：研究与实验 4 区 药学
最新[2025]版：
大类 | 4 区 医学
小类 | 4 区 医学：研究与实验 4 区 药学
JCR分区：
出版当年[2018]版：
Q4 PHARMACOLOGY & PHARMACY Q4 MEDICINE, RESEARCH & EXPERIMENTAL
最新[2023]版：
Q4 MEDICINE, RESEARCH & EXPERIMENTAL Q4 PHARMACOLOGY & PHARMACY

影响因子： 最新[2023版] 最新五年平均 出版当年[2018版] 出版当年五年平均 出版前一年[2017版] 出版后一年[2019版]

第一作者：
第一作者机构： [1]Department of Cardiology, The Second AffiliatedHospital of Guangzhou University of Chinese Medicine,Guangzhou, Guangdong, P.R. China
通讯作者：
通讯机构： [1]Department of Cardiology, The Second AffiliatedHospital of Guangzhou University of Chinese Medicine,Guangzhou, Guangdong, P.R. China [4]Postdoctoral Research Center, Fujian University ofTraditional Chinese Medicine, Fujian, P.R. China [*1]Department of Cardiology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, 111 Dade Road, Guangzhou, Guangdong 510020, P.R. China.
推荐引用方式(GB/T 7714)：
Huang M,Wu H,Wu J,et al.Prevention of platelet aggregation and arterial thrombosis using a modified Shenzhu Guanxin Formula[J].JOURNAL OF INTERNATIONAL MEDICAL RESEARCH.2020,48(10):doi:10.1177/0300060520941326.
APA：
Huang, M,Wu, H,Wu, J,Chen, Q,Zou, D&Xu, D.(2020).Prevention of platelet aggregation and arterial thrombosis using a modified Shenzhu Guanxin Formula.JOURNAL OF INTERNATIONAL MEDICAL RESEARCH,48,(10)
MLA：
Huang, M,et al."Prevention of platelet aggregation and arterial thrombosis using a modified Shenzhu Guanxin Formula".JOURNAL OF INTERNATIONAL MEDICAL RESEARCH 48..10(2020)

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