机构：[1]Department of Gastrointestinal Surgery, Guangdong Province Hospital of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China大德路总院肛肠科大德路总院肛肠科广东省中医院[2]Department of Cell Biology & Institute of Biomedicine, National Engineering Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of Bioengineering Medicine, College of Life Science and Technology, Jinan University, Guangzhou, Guangdong, China[3]Chemical Biology Center, Lishui Institute of Agricultural Sciences, Lishui, Zhejiang, China[4]Department of Gastrointestinal Surgery, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China深圳市中医院深圳医学信息中心[5]Department of General Surgery, Zhuhai Hospital of Integrated Traditional Chinese and Western Medicine, Zhuhai, Guangdong, China.
Caragaphenol A (CAA) is a novel resveratrol trimer isolated from the roots of Caraganastenophylla. However, the biological activity of CAA is still unknown. In the present study, we investigated the anticancer effects of CAA on gastric cancer cells. CAA selectively inhibited cell growth of human gastric cancer cells. Moreover, CAA potently induced cell cycle arrest at G2/M phase and apoptosis with the increased intracellular reactive oxidative species (ROS) level. Inhibition of ROS could partially rescue CAA-induced cell apoptosis. Additionally, DNA is not the target of CAA. CAA in combination with DDP or 5FU synergistically inhibited the growth of human gastric cancer cells. Altogether, our study provides the evidence for the potential therapeutic application of CAA on human gastric cancer.
基金：
This work was supported by funds from the
National Natural Science Foundation of China
Nos. 31271444, 81201726, 8161101021 (Z.
Shi) and 81303305 (K. Cheng), the Lishui
Science and Technology Bureau Research Fund
No. 20140212037 (K. Cheng), the Guangdong
Natural Science Funds for Distinguished Young
Scholar No. 2014A030306001 (Z. Shi), the
Science and Technology Program of Guangdong
No. 2016A050502027 (Z. Shi), the
Science and Technology Program of Guangzhou
No. 201704030058 (Z. Shi), and the Foundation
for Research Cultivation and Innovation of
Jinan University No. 21616119 (Z. Shi).
基金编号：Z.Shi
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2016]版：
大类|3 区医学
小类|3 区医学：研究与实验3 区肿瘤学
最新[2025]版：
大类|4 区医学
小类|4 区医学：研究与实验4 区肿瘤学
第一作者：
第一作者机构：[1]Department of Gastrointestinal Surgery, Guangdong Province Hospital of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China[5]Department of General Surgery, Zhuhai Hospital of Integrated Traditional Chinese and Western Medicine, Zhuhai, Guangdong, China.
共同第一作者：
通讯作者：
通讯机构：[1]Department of Gastrointestinal Surgery, Guangdong Province Hospital of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China[2]Department of Cell Biology & Institute of Biomedicine, National Engineering Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of Bioengineering Medicine, College of Life Science and Technology, Jinan University, Guangzhou, Guangdong, China[*1]Department of Cell Biology & Institute of Biomedicine, National Engineering Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of Bioengineering Medicine, College of Life Science and Technology, Jinan University, Room 708, The 2nd Engineer and Scientific Building, 601 Huangpu Road West, Guangzhou 510632, China.[*2]Department of Gastrointestinal Surgery, Guangdong Province Hospital of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, 111 Dade Road, Guangzhou 510120, Guangdong, China.
推荐引用方式(GB/T 7714)：
Qi-Qi Peng,Kun Wang,Ke-Jun Cheng,et al.Caragaphenol a induces reactive oxygen species related apoptosis in human gastric cancer cells.[J].American journal of translational research.2017,9(8):3804-3815.
APA：
Qi-Qi Peng,Kun Wang,Ke-Jun Cheng,Hai-Gan Yang,Jian-Ge Qiu...&Wei Wang.(2017).Caragaphenol a induces reactive oxygen species related apoptosis in human gastric cancer cells..American journal of translational research,9,(8)
MLA：
Qi-Qi Peng,et al."Caragaphenol a induces reactive oxygen species related apoptosis in human gastric cancer cells.".American journal of translational research 9..8(2017):3804-3815
