个人中心| | 帮助
高级检索
当前位置： 首页 > 详情页

Caragaphenol a induces reactive oxygen species related apoptosis in human gastric cancer cells

| 认领 | 导出 |

文献详情

资源类型：
作者：
Qi-Qi Peng[1,5] * ; Kun Wang[2] * ; Ke-Jun Cheng[3] * ; Hai-Gan Yang[4] ; Jian-Ge Qiu[2] ; Wen-Ji Zhang[2] ; Qi-Wei Jiang[2] ; YangYang[2] ; Di-Wei Zheng[2] ; Jia-Rong Huang[2] ; Meng-Ning Wei[2] ; Zhi Shi[2,*1] ; Wei Wang[1,*2] ;
机构： [1]Department of Gastrointestinal Surgery, Guangdong Province Hospital of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China [2]Department of Cell Biology & Institute of Biomedicine, National Engineering Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of Bioengineering Medicine, College of Life Science and Technology, Jinan University, Guangzhou, Guangdong, China [3]Chemical Biology Center, Lishui Institute of Agricultural Sciences, Lishui, Zhejiang, China [4]Department of Gastrointestinal Surgery, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China [5]Department of General Surgery, Zhuhai Hospital of Integrated Traditional Chinese and Western Medicine, Zhuhai, Guangdong, China
出处：
ISSN：

关键词： Apoptosis Caragaphenol A Gastric cancer Reactive oxidative species Resveratrol trimer

摘要：
Caragaphenol A (CAA) is a novel resveratrol trimer isolated from the roots of Caraganastenophylla. However, the biological activity of CAA is still unknown. In the present study, we investigated the anticancer effects of CAA on gastric cancer cells. CAA selectively inhibited cell growth of human gastric cancer cells. Moreover, CAA potently induced cell cycle arrest at G2/M phase and apoptosis with the increased intracellular reactive oxidative species (ROS) level. Inhibition of ROS could partially rescue CAA-induced cell apoptosis. Additionally, DNA is not the target of CAA. CAA in combination with DDP or 5FU synergistically inhibited the growth of human gastric cancer cells. Altogether, our study provides the evidence for the potential therapeutic application of CAA on human gastric cancer. © 2017, E-Century Publishing Corporation. All rights reserved.

基金：
This work was supported by funds from the National Natural Science Foundation of China Nos. 31271444, 81201726, 8161101021 (Z. Shi) and 81303305 (K. Cheng), the Lishui Science and Technology Bureau Research Fund No. 20140212037 (K. Cheng), the Guangdong Natural Science Funds for Distinguished Young Scholar No. 2014A030306001 (Z. Shi), the Science and Technology Program of Guangdong No. 2016A050502027 (Z. Shi), the Science and Technology Program of Guangzhou No. 201704030058 (Z. Shi), and the Foundation for Research Cultivation and Innovation of Jinan University No. 21616119 (Z. Shi).
语种：
外文
中科院(CAS)分区：
出版当年[2016]版：
大类 | 3 区 医学
小类 | 3 区 医学：研究与实验 3 区 肿瘤学
最新[2025]版：
大类 | 4 区 医学
小类 | 4 区 医学：研究与实验 4 区 肿瘤学
第一作者：
第一作者机构： [1]Department of Gastrointestinal Surgery, Guangdong Province Hospital of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China [5]Department of General Surgery, Zhuhai Hospital of Integrated Traditional Chinese and Western Medicine, Zhuhai, Guangdong, China
共同第一作者：
通讯作者：
通讯机构： [1]Department of Gastrointestinal Surgery, Guangdong Province Hospital of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China [2]Department of Cell Biology & Institute of Biomedicine, National Engineering Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of Bioengineering Medicine, College of Life Science and Technology, Jinan University, Guangzhou, Guangdong, China [*1]Department of Cell Biology & Institute of Biomedicine, National Engineering Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of Bioengineering Medicine, College of Life Science and Technology, Jinan University, Room 708, The 2nd Engineer and Scientific Building, 601 Huangpu Road West, Guangzhou 510632, China [*2]Department of Gastrointestinal Surgery, Guangdong Province Hospital of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, 111 Dade Road, Guangzhou 510120, Guangdong, China.
推荐引用方式(GB/T 7714)：
Qi-Qi Peng,Kun Wang,Ke-Jun Cheng,et al.Caragaphenol a induces reactive oxygen species related apoptosis in human gastric cancer cells[J].American Journal of Translational Research.2017,9(8):
APA：
Qi-Qi Peng,Kun Wang,Ke-Jun Cheng,Hai-Gan Yang,Jian-Ge Qiu...&Wei Wang.(2017).Caragaphenol a induces reactive oxygen species related apoptosis in human gastric cancer cells.American Journal of Translational Research,9,(8)
MLA：
Qi-Qi Peng,et al."Caragaphenol a induces reactive oxygen species related apoptosis in human gastric cancer cells".American Journal of Translational Research 9..8(2017)

相关文献

[1]Caragaphenol a induces reactive oxygen species related apoptosis in human gastric cancer cells [2]Caragaphenol a induces reactive oxygen species related apoptosis in human gastric cancer cells. [3]广金钱草水提取液对肾草酸钙结石模型大鼠氧化应激的影响研究 [4]Rutin maintains redox balance to relieve oxidative stress induced by TBHP in nucleus pulposus cells. [5]Downregulation of KMT2D suppresses proliferation and induces apoptosis of gastric cancer [6]miR-922 regulates apoptosis, migration, and invasion by targeting SOCS1 in gastric cancer. [7]Yangzheng Sanjie decoction regulates proliferation and apoptosis of gastric cancer cells by enhancing let-7a expression [8]Yangzheng Sanjie decoction regulates proliferation and apoptosis of gastric cancer cells by enhancing let-7a expression [9]Wogonin inhibits oxidative stress and vascular calcification via modulation of heme oxygenase-1 [10]“腰三针”干预腰多裂肌损伤大鼠多种氧化应激因子的表达

资源点击量：2018 今日访问量：0 总访问量：645 更新日期：2024-07-01 建议使用谷歌、火狐浏览器 常见问题

版权所有©2020 广东省中医院 技术支持：重庆聚合科技有限公司 地址：广州市越秀区大德路111号