机构：[1]Laboratory of Traditional Chinese Medicine and Marine Drugs, School of Life Sciences, Sun Yat-Sen University, Guangzhou 510275, China[2]Edwin L. Steele Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA[3]Sunnybrook Health Sciences Centre and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada[4]Guangdong Laboratory Animals Monitoring Institute, Guangdong Key Laboratory of Laboratory Animals, Guangzhou 510663, China[5]Cancer center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China华中科技大学同济医学院附属协和医院
Glioblastoma multiforme is the most aggressive and common primary brain tumor, and is virtually incurable due to its therapeutic resistance to radiation and chemotherapy. Curcumin is a well-known phytochemical exhibiting antitumor activity on many human cancers including glioblastoma multiforme. Given the unique miRNA expression profiles in cancer cells compared to non-cancerous cells, we investigated whether these miRNA could be used to cancer therapy. In this report we show that miR-378, a glioblastoma multiforme down regulated miRNA, may enhance the inhibitory effect of curcumin on this cancer growth. Our results indicated that the inhibitory effect of curcumin was enhanced in miR-378-expressing stable U87 cells in vitro and in vivo, compared to control cells. MiR-378 was found to target p-p38 expression, underlying the observed phenotypic changes. Thus, we concluded that miR-378 enhances the response of glioblastoma multiforme to curcumin treatment, by targeting p38.
基金：
Support by Federal Share/NCI Proton Beam Program Income Funding (222480, Peigen Huang), and The Science and Technology Project of Guangdong Province, China: 2015A04040426 & 2016A040403064 (Wende Li). The Guangdong Natural Science Foundation (2015A030313092), The Foundation of Guangdong key S&T Special Projects (2013A022100025) and the Agricultural Science and Technology Achievements Transformation Foundation of China (2014GB2E00047).
第一作者机构：[1]Laboratory of Traditional Chinese Medicine and Marine Drugs, School of Life Sciences, Sun Yat-Sen University, Guangzhou 510275, China[2]Edwin L. Steele Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA[4]Guangdong Laboratory Animals Monitoring Institute, Guangdong Key Laboratory of Laboratory Animals, Guangzhou 510663, China
通讯作者：
推荐引用方式(GB/T 7714)：
Wende Li,Weining Yang,Yujiao Liu,et al.MicroRNA-378 enhances inhibitory effect of curcumin on glioblastoma.[J].ONCOTARGET.2017,8(43):73938-73946.doi:10.18632/oncotarget.17881.
APA：
Wende Li,Weining Yang,Yujiao Liu,Siyu Chen,Shanmin Chin...&Donghui Xu.(2017).MicroRNA-378 enhances inhibitory effect of curcumin on glioblastoma..ONCOTARGET,8,(43)
MLA：
Wende Li,et al."MicroRNA-378 enhances inhibitory effect of curcumin on glioblastoma.".ONCOTARGET 8..43(2017):73938-73946
医学