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Calycosin inhibits migration and invasion through modulation of transforming growth factor beta-mediated mesenchymal properties in U87 and U251 cells.

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收录情况： ◇ SCIE

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机构： [1]Department of Neurosurgery, Huzhou Central Hospital, Huzhou, Zhejiang, People’s Republic of China [2]Nanchang University Medical College, Nanchang, Jiangxi, People’s Republic of China [3]Department of Gastroenterology, The 98th Hospital of Nanjing Military Command, Huzhou, Zhejiang, People’s Republic of China [4]Spleen & Stomach Institute, Guangzhou University of Traditional Chinese Medicine, Guangzhou, Guangdong, People’s Republic of China [5]Department of Neurosurgery, China-Japan Friendship Hospital, Beijing, People’s Republic of China [6]Bayi Brain Hospital, The Military General Hospital of Beijing PLA, Beijing, People’s Republic of China

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关键词： calycosin migration invasion epithelial-mesenchymal transition (EMT) matrix metalloproteinases (MMPs) glioblastoma

摘要：

In this study, we investigated the potential anticancer effects of calycosin against human glioblastoma cells, including the impacts on cell proliferation, apoptosis, and cell cycle distribution. We further studied its inhibitory activity on migration and invasion in U87 and U251 cells. Furthermore, transforming growth factor beta-mediated reductions of mesenchymal-associated genes/activators, matrix metalloproteinases-2, and -9 were detected in this process. Administration of calycosin in a glioblastoma xenograft model showed that calycosin could not only reduce tumor volume but also suppress transforming growth factor beta as well as its downstream molecules. These results revealed calycosin as a potential antitumor agent in human glioblastoma.

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出版当年[2015]版：

大类 | 3 区医学

小类 | 3 区药物化学 3 区药学

最新[2025]版：

大类 | 2 区医学

小类 | 2 区药物化学 2 区药学

JCR分区：

出版当年[2014]版：

Q2 CHEMISTRY, MEDICINAL Q2 PHARMACOLOGY & PHARMACY

最新[2023]版：

Q1 CHEMISTRY, MEDICINAL Q1 PHARMACOLOGY & PHARMACY

影响因子： 4.7 最新[2023版] 4.8 最新五年平均 3.028 出版当年[2014版] 3.033 出版当年五年平均 3.026 出版前一年[2013版] 2.881 出版后一年[2015版]

第一作者：

第一作者机构： [1]Department of Neurosurgery, Huzhou Central Hospital, Huzhou, Zhejiang, People’s Republic of China

共同第一作者：

通讯作者：

通讯机构： [5]Department of Neurosurgery, China-Japan Friendship Hospital, Beijing, People’s Republic of China [6]Bayi Brain Hospital, The Military General Hospital of Beijing PLA, Beijing, People’s Republic of China [*1]Department of Neurosurgery, China-Japan Friendship Hospital, Yinghua East Street, Beijing 100029, People’s Republic of China [*2]Bayi Brain Hospital, The Military General Hospital of Beijing PLA , No 5 Nanmen Cang, Beijing 100700, People’s R epublic of China

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