机构：[1]School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China[2]Medical Research Department, Guangdong General Hospital and Guangdong Academy of Medical Sciences, Guangzhou 510080, China广东省人民医院[3]HKBU Institute of Research and Continuing Education, Shenzhen 518057, China
Mitochondria play a key role in various cell processes including ATP production, Ca2+ homeostasis, reactive oxygen species (ROS) generation, and apoptosis. The selective removal of impaired mitochondria by autophagosome is known as mitophagy. Cerebral ischemia is a common form of stroke caused by insufficient blood supply to the brain. Emerging evidence suggests that mitophagy plays important roles in the pathophysiological process of cerebral ischemia. This review focuses on the relationship between ischemic brain injury and mitophagy. Based on the latest research, it describes how the signaling pathways of mitophagy appear to be involved in cerebral ischemia.
基金：
This work was funded by the Faculty Research Grant of
Hong Kong Baptist University (FRG2/15-16/022) and the
Guandong Natural Science Foundation (2014A030313766
and 2016A030313008).
第一作者机构：[1]School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China
通讯作者：
通讯机构：[1]School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China[3]HKBU Institute of Research and Continuing Education, Shenzhen 518057, China
推荐引用方式(GB/T 7714)：
Tang Yan-Cheng,Tian Hong-Xia,Yi Tao,et al.The critical roles of mitophagy in cerebral ischemia.[J].PROTEIN & CELL.2016,7(10):699-713.doi:10.1007/s13238-016-0307-0.
APA：
Tang Yan-Cheng,Tian Hong-Xia,Yi Tao&Chen Hu-Biao.(2016).The critical roles of mitophagy in cerebral ischemia..PROTEIN & CELL,7,(10)
MLA：
Tang Yan-Cheng,et al."The critical roles of mitophagy in cerebral ischemia.".PROTEIN & CELL 7..10(2016):699-713
生物学