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Extraction, characterization and bioactivities of novel purified polysaccharides from Baphicacanthis Cusiae Rhizoma et Radix.

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收录情况： ◇ SCIE

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机构： [a]School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong, PR China [b]Huai’an First People’s Hospital, Nanjing Medical University, Huai’an 223300, Jiangsu, PR China [c]Affiliated Huai’an Hospital of Xuzhou Medical University, Huai’an 223001, Jiangsu, PR China [d]Xinhua College, Sun Yat-sen University, Guangzhou 510520, Guangdong, PR China [e]Pingguang Pharmaceutical Co., Ltd., Hefei 231131, PR China

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关键词： Baphicacanthis Cusiae Rhizoma et Radix Polysaccharide Anti-inflammatory activity

摘要：

The purpose of this study was to investigate the extraction, characterization and bioactivities of purified water-soluble polysaccharides (BCP) from Baphicacanthis Cusiae Rhizoma et Radix. Based on the response surface methodology, the optimal extraction parameters were obtained as follows: extraction temperature of 60.0°C, extraction time of 35.0min, and ratio of water to raw material of 24.5ml/g. Then, BCP was separated and purified by chromatography of DEAE-52 and Sephadex G-100, and obtained two purified fractions, named as BCP-1 and BCP-2. Their molecular weights were respectively 11.6 and 26.7 KDa with mainly composed of glucose, arabinose and galactose. BCP-2 had higher contents of sulfuric radical and uronic acid than BCP-1. Finally, their antioxidant and anti-inflammatory activities were evaluated. Both of BCP-1 and BCP-2 exhibited strong antioxidant activity in vitro, and the antioxidant of BCP-2 was better. Besides, they showed ideal anti-inflammatory activity in vitro and in vivo. Copyright © 2016 Elsevier B.V. All rights reserved.

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出版当年[2015]版：

大类 | 3 区生物

小类 | 4 区生化与分子生物学

最新[2025]版：

大类 | 2 区

生物学

小类 | 2 区生化与分子生物学 2 区应用化学 2 区高分子科学

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出版当年[2014]版：

Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

最新[2023]版：

Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Q1 CHEMISTRY, APPLIED Q1 POLYMER SCIENCE

影响因子： 7.7 最新[2023版] 7.7 最新五年平均 2.858 出版当年[2014版] 3.016 出版当年五年平均 3.096 出版前一年[2013版] 3.138 出版后一年[2015版]

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第一作者机构： [a]School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong, PR China

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