机构：[1]Sun Yat‐sen University Cancer Center, State Key Laboratory of Oncology in South China, Department of Experimental Research, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, Guangdong, China[2]Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou 510623, Guangdong, China[3]Department of Oncology, The First Affiliated Hospital of Sun Yat‐sen University, Guangzhou 510080, Guangdong, China[4]School of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong 999077, China[5]Molecular Epidemiology Laboratory and Department of Laboratory Medicine, Harbin Medical University Cancer Hospital, Harbin 150040, Heilongjiang, China[6]Department of Medical Genetics, Zhongshan School of Medicine, Sun Yat‐sen University, Guangzhou 510080,Guangdong, China[7]Department of Radiation Oncology, The First Affiliated Hospital of Sun Yat‐sen University, Guangzhou 510080, Guangdong, China
Xeroderma pigmentosum group G (XPG) recognizes and excises DNA damage on the 3' side during the DNA repair process. Previous studies indicated that XPG gene polymorphisms may associate with gastric cancer susceptibility, but results were inconsistent. We evaluated the association of five potentially functional XPG polymorphisms (rs2094258 C>T, rs751402 C>T, rs2296147 T>C, rs1047768 T>C, and rs873601 G>A) with gastric cancer susceptibility in 1142 gastric cancer cases and 1173 controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using logistic regression models. Overall, no significant association was detected between any of selected polymorphism and gastric cancer risk. However, we found that individuals carrying 3-4 risk genotypes were at significantly higher risk of gastric cancer than those with 0-2 risk genotypes (OR=1.32, 95% CI=1.04-1.68, P=0.021). The stratification analysis revealed that the cumulative effect of risk genotypes (3-4 vs. 0-2) on gastric cancer were more prominent among subgroups older than 58 years and men. In conclusion, our results indicated that none of the selected XPG polymorphism could significantly alter gastric cancer susceptibility alone. These polymorphisms might collectively confer increased gastric cancer susceptibility. These findings would be strengthened by larger prospective multicenter studies involving different ethnic populations.
基金：
National Natural Science Foundation of China (Grant No.
81502046), Special Financial Grant from the China
Postdoctoral Science Foundation (Grant No.
2014T70836), the Natural Science Foundation of
Guangdong Province (Grant No. 2015A030310324),
and the National Science Fund for Distinguished Young
Scholars (Grant No. 81325018).
第一作者机构：[1]Sun Yat‐sen University Cancer Center, State Key Laboratory of Oncology in South China, Department of Experimental Research, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, Guangdong, China[3]Department of Oncology, The First Affiliated Hospital of Sun Yat‐sen University, Guangzhou 510080, Guangdong, China
共同第一作者：
通讯作者：
通讯机构：[1]Sun Yat‐sen University Cancer Center, State Key Laboratory of Oncology in South China, Department of Experimental Research, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, Guangdong, China[2]Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou 510623, Guangdong, China[7]Department of Radiation Oncology, The First Affiliated Hospital of Sun Yat‐sen University, Guangzhou 510080, Guangdong, China
推荐引用方式(GB/T 7714)：
Rui‐Xi Hua,Zhen‐Jian Zhuo,Jinhong Zhu,et al.Association between genetic variants in the XPG gene and gastric cancer risk in a Southern Chinese population.[J].AGING-US.2016,8(12):3311-+.doi:10.18632/aging.101119.
APA：
Rui‐Xi Hua,Zhen‐Jian Zhuo,Jinhong Zhu,Dan‐Hua Jiang,Wen‐Qiong Xue...&Jing He.(2016).Association between genetic variants in the XPG gene and gastric cancer risk in a Southern Chinese population..AGING-US,8,(12)
MLA：
Rui‐Xi Hua,et al."Association between genetic variants in the XPG gene and gastric cancer risk in a Southern Chinese population.".AGING-US 8..12(2016):3311-+
