A mixture of apple pomace and rosemary extract improves fructose consumption-induced insulin resistance in rats: modulation of sarcolemmal CD36 and glucose transporter-4.
机构：[1]Faculty of Basic Medical Sciences, Chongqing Medical University, Chongqing 400016, China[2]The Laboratory of Traditional Chinese Medicine, Chongqing Medical University, Chongqing 400016, China[3]Endocrinology and Metabolism Group, Sydney Institute of Health Sciences/Sydney Institute of Traditional Chinese Medicine, NSW 2000, Australia[4]Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine, and The Institute of Chinese Medicine, Guangdong Pharmaceutical University, China[5]Central Clinical School, Royal Prince Alfred Hospital, The University of Sydney, Australia[6]Pharmafood Institute, Kyoto 602-8136, Japan
Apple pomace is a by-product of the processing of apple for juice, cider or wine preparation. Rosemary is a herb commonly used as spice and flavoring agent in food processing. Evidence suggests that both apple pomace and rosemary have rich bioactive molecules with numerous metabolic effects. To provide more information for using apple pomace and rosemary as functional foods for management of metabolism-associated disorders, the present study investigated the insulin-sensitizing effect of a mixture of apple pomace and rosemary extract (AR). The results showed that treatment with AR (500 mg/kg, daily, by gavage) for 5 weeks attenuated chronic liquid fructose consumption-induced increases in fasting plasma insulin concentration, the homeostasis model assessment of insulin resistance index and the adipose tissue insulin resistance index in rats. Mechanistically, AR suppressed fructose-induced acceleration of the clearance of plasma non-esterified fatty acids during oral glucose tolerance test, and decreased excessive triglyceride accumulation and the increased Oil Red O staining area in the gastrocnemius. Furthermore, AR restored fructose-induced overexpression of sarcolemmal CD36 that is known to contribute to etiology of insulin resistance by facilitating fatty acid uptake, and downregulation of sarcolemmal glucose transporter (GLUT)-4 that is the insulin-responsive glucose transporter. Thus, these results demonstrate that AR improves fructose-induced insulin resistance in rats via modulation of sarcolemmal CD36 and GLUT-4.
基金：
This work was supported financially by the
grants from the National Natural Science
Foundation of China, China (Grant No:
81374033), the Natural Science Foundation
of Chongqing Medical University, China (Grant
No: X12100), and R&D Agency for Curative
Natural Products (a Japanese government-registered
non-profit organization), Kyoto, Japan.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2015]版：
大类|3 区医学
小类|3 区医学：研究与实验3 区肿瘤学
最新[2025]版：
大类|4 区医学
小类|4 区医学：研究与实验4 区肿瘤学
第一作者：
第一作者机构：[1]Faculty of Basic Medical Sciences, Chongqing Medical University, Chongqing 400016, China
通讯作者：
通讯机构：[2]The Laboratory of Traditional Chinese Medicine, Chongqing Medical University, Chongqing 400016, China[3]Endocrinology and Metabolism Group, Sydney Institute of Health Sciences/Sydney Institute of Traditional Chinese Medicine, NSW 2000, Australia[*1]The Laboratory of Traditional Chinese Medicine, Chongqing Medical University, 1 Yixueyuan Road, Yuzhong District, Chongqing 400016, China.[*2]Endocrinology and Metabolism Group, Sydney Institute of Health Sciences/Sydney Institute of Traditional Chinese Medicine, Level 5, 545 Kent Street, Sydney NSW 2000, Australia.
推荐引用方式(GB/T 7714)：
Peng Ma,Ling Yao,Xuemei Lin,et al.A mixture of apple pomace and rosemary extract improves fructose consumption-induced insulin resistance in rats: modulation of sarcolemmal CD36 and glucose transporter-4.[J].American journal of translational research.2016,8(9):3791-3801.
APA：
Peng Ma,Ling Yao,Xuemei Lin,Tieguang Gu,Xianglu Rong...&Yuhao Li.(2016).A mixture of apple pomace and rosemary extract improves fructose consumption-induced insulin resistance in rats: modulation of sarcolemmal CD36 and glucose transporter-4..American journal of translational research,8,(9)
MLA：
Peng Ma,et al."A mixture of apple pomace and rosemary extract improves fructose consumption-induced insulin resistance in rats: modulation of sarcolemmal CD36 and glucose transporter-4.".American journal of translational research 8..9(2016):3791-3801
