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Rosiglitazone ameliorates skeletal muscle insulin resistance by decreasing free fatty acids release from adipocytes.

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收录情况： ◇ SCIE

作者：
Longlong Gong[a,b] * ; Huan Jin[a] ; Yonghua Li[a] ; Yingyao Quan[c] ; Jichun Yang[d] ; Qing Tang[a] ; Zhengzhi Zou[a,b,*1] ;
机构： [a]MOE Key Laboratory of Laser Life Science, Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou, 510631, China [b]Guangdong Provincial Key Laboratory of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou, 510631, China [c]Zhuhai Interventional Medical Center, Zhuhai Precision Medical Center, Zhuhai Hospital of Jinan University, Zhuhai People’s Hospital, Zhuhai, Guangdong, 519000, China [d]School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 300193, China
出处：
DOI： 10.1016/j.bbrc.2020.09.144
ISSN：

关键词： Skeletal muscle Adipocytes Rosiglitazone Free fatty acids Insulin resistance

摘要：
Skeletal muscle and white adipose tissue are important organs of glucose-lipid metabolism. However, excessive lipolysis and free fatty acids (FFA) release in adipocytes elevate plasma FFA, leading to insulin resistance in skeletal muscle. Here, we investigated effects of insulin-resistant adipocytes on skeletal muscle in vitro by simulating body environment using a transwell coculture method. Insulin-resistant 3T3-L1 adipocytes increased lipolysis and FFA release, which reduced insulin sensitivity in the cocultured C2C12 myotubes. Rosiglitazone (RSG) decreased excessive lipolysis by reducing expression of adipose triglyceride lipase (ATGL) and activity of hormone-sensitive lipase (HSL), which led to decrease of FFA release from insulin-resistant 3T3-L1 adipocytes. Meanwhile, insulin resistance in C2C12 myotubes cocultured with insulin-resistant 3T3-L1 adipocytes was ameliorated after RSG treatment. Taken together, our present study provided direct evidence to better understand insulin resistance between skeletal muscle and adipose tissue in type 2 diabetes. Copyright © 2020 Elsevier Inc. All rights reserved.

基金：
The study was supported by National Natural Science Foundation of China (81772803 and 81972479), Science and Technology Program of Guangzhou (2019050001), Scientific and Technological Planning Project of Guangzhou City (201805010002 and 201904010038), the Natural Science Foundation of Guangdong province (2019A1515011100), China Postdoctoral Science Foundation (2019M653270).
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外文
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中科院(CAS)分区：
出版当年[2019]版：
大类 | 3 区 生物
小类 | 3 区 生物物理 4 区 生化与分子生物学
最新[2025]版：
大类 | 4 区 生物学
小类 | 4 区 生化与分子生物学 4 区 生物物理
JCR分区：
出版当年[2018]版：
Q2 BIOPHYSICS Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
最新[2023]版：
Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Q3 BIOPHYSICS

影响因子： 最新[2023版] 最新五年平均 出版当年[2018版] 出版当年五年平均 出版前一年[2017版] 出版后一年[2019版]

第一作者：
第一作者机构： [a]MOE Key Laboratory of Laser Life Science, Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou, 510631, China [b]Guangdong Provincial Key Laboratory of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou, 510631, China
通讯作者：
通讯机构： [a]MOE Key Laboratory of Laser Life Science, Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou, 510631, China [b]Guangdong Provincial Key Laboratory of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou, 510631, China [*1]MOE Key Laboratory of Laser Life Science, Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou, 510631, China.
推荐引用方式(GB/T 7714)：
Longlong Gong,Huan Jin,Yonghua Li,et al.Rosiglitazone ameliorates skeletal muscle insulin resistance by decreasing free fatty acids release from adipocytes.[J].BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS.2020,533(4):1122-1128.doi:10.1016/j.bbrc.2020.09.144.
APA：
Longlong Gong,Huan Jin,Yonghua Li,Yingyao Quan,Jichun Yang...&Zhengzhi Zou.(2020).Rosiglitazone ameliorates skeletal muscle insulin resistance by decreasing free fatty acids release from adipocytes..BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,533,(4)
MLA：
Longlong Gong,et al."Rosiglitazone ameliorates skeletal muscle insulin resistance by decreasing free fatty acids release from adipocytes.".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 533..4(2020):1122-1128

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