机构：[1]Respiratory Department, The First Affiliated Hospital of Sun Yat-Sen University, Institute of Respiratory Diseases of Sun Yat-Sen University, Guangzhou, Guangdong, People’s Republic of China中山大学附属第一医院[2]Respiratory Department, Nanchang Hospital of Integrative Traditional Chinese and Western Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi, People's Republic of China[3]Department of Pathology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, People’s Republic of China中山大学附属第一医院
Sirtuin6 (SIRT6), a member of the sirtuins protein family, plays multiple complex roles in cancer. Here, we report that elevated SIRT6 expression was correlated with clinicopathological parameters such as T and N classification in non-small cell lung cancer (NSCLC) patient tumors. SIRT6 overexpression in NSCLC cell lines increased extracellular signal-regulated kinase (p-ERK)1/2 phosphorylation, activated matrix metalloproteinase 9 (MMP9) and promoted tumor cell migration and invasion. Upon treatment with a specific mitogen-activated protein kinase (MEK) 1/2 inhibitor, these effects were abolished. Our results demonstrate SIRT6 upregulation in NSCLC for the first time and suggest a functional role for SIRT6 in promoting migration and invasion through ERK1/2/MMP9 signaling. SIRT6 may serve as a potential therapeutic target in NSCLC and its utility as a prognostic indicator warrants further study.
基金：
This work was supported by the Science and Technology Planning Project of Guangdong Province, China (2009 B03081171), the Science and Technology Planning Project of Guangzhou Science and Technology Council (09A7d2060166), the Natural Science Foundation of China (81460444) and National Natural Science Foundation of China (81502492) and the Natural Science Funds of Jiangxi Province (20151511010007).
第一作者机构：[1]Respiratory Department, The First Affiliated Hospital of Sun Yat-Sen University, Institute of Respiratory Diseases of Sun Yat-Sen University, Guangzhou, Guangdong, People’s Republic of China
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通讯作者：
推荐引用方式(GB/T 7714)：
Lihong Bai,Gengpeng Lin,Longhua Sun,et al.Upregulation of SIRT6 predicts poor prognosis and promotes metastasis of non-small cell lung cancer via the ERK1/2/MMP9 pathway.[J].ONCOTARGET.2016,7(26):40377-40386.doi:10.18632/oncotarget.9750.
APA：
Lihong Bai,Gengpeng Lin,Longhua Sun,Yangli Liu,Xinyan Huang...&Canmao Xie.(2016).Upregulation of SIRT6 predicts poor prognosis and promotes metastasis of non-small cell lung cancer via the ERK1/2/MMP9 pathway..ONCOTARGET,7,(26)
MLA：
Lihong Bai,et al."Upregulation of SIRT6 predicts poor prognosis and promotes metastasis of non-small cell lung cancer via the ERK1/2/MMP9 pathway.".ONCOTARGET 7..26(2016):40377-40386
医学