机构：[1]The Endocrine Institute and The Liaoning Provincial Key Laboratory of Endocrine Diseases, Department of Endocrinology and Metabolism, The First Hospital of China Medical University, Liaoning,China.[2]Department of Endocrinology and Metabolism, Jiangsu Province Hospital on Integration of Chinese and Western Medicine, Nanjing University of Traditional Chinese Medicine, Jiangsu,China.江苏省人民医院[3]Guangdong Provincial Key Laboratory of Diabetology, Department of Endocrinology and Metabolic Disease, The Third Affiliated Hospital of Sun Yat-Sen University, Guangdong, China.中山大学附属第三医院
The purpose of this study was to establish normal thyroglobulin (Tg) reference intervals (RIs) in regions with adequate and more than adequate iodine intake according to the National Academy of Clinical Biochemistry (NACB) guidelines and to investigate the relationships between Tg and other factors.A total of 1317 thyroid disease-free adult subjects (578 men, 739 nonpregnant women) from 2 cities (Guangzhou and Nanjing) were enrolled in this retrospective, observational study. Each subject completed a questionnaire and underwent physical and ultrasonic examination. Serum Tg, thyroid-stimulating hormone (TSH), thyroid peroxidase antibody (TPOAb), Tg antibody (TgAb), and urinary iodine concentration (UIC) were measured. Reference groups were established on the basis of TSH levels: 0.5 to 2.0 and 0.27 to 4.2 mIU/L.The Tg RIs for Guangzhou and Nanjing were 1.6 to 30.0 and 1.9 to 25.8 ng/mL, respectively. No significant differences in Tg were found between genders or among different reference groups. Stepwise linear regression analyses showed that TgAb, thyroid volume, goiter, gender, age, and TSH levels were correlated with Tg.In adults from regions with adequate and more than adequate iodine intake, we found that Tg may be a suitable marker of iodine status; gender-specific Tg RI was unnecessary; there was no difference between Tg RIs in regions with adequate and more than adequate iodine intake; and the TSH criterion for selecting the Tg reference population could follow the local TSH reference rather than 0.5 to 2.0 mIU/L.
基金：
This work was supported by the Research Foundation of Key
Laboratory of Endocrine Diseases, Department of Science and Technology,
Shenyang Government, Liaoning province, China (Grant F11-244-1-00)
第一作者机构：[1]The Endocrine Institute and The Liaoning Provincial Key Laboratory of Endocrine Diseases, Department of Endocrinology and Metabolism, The First Hospital of China Medical University, Liaoning,China.
通讯作者：
通讯机构：[1]The Endocrine Institute and The Liaoning Provincial Key Laboratory of Endocrine Diseases, Department of Endocrinology and Metabolism, The First Hospital of China Medical University, Liaoning,China.[*1]The First Hospital of China Medical University, No. 155, Nanjing North Street, Heping District, Shenyang, Liaoning 110001, China
推荐引用方式(GB/T 7714)：
Wang Zhaojun,Zhang Hanyi,Zhang Xiaowen,et al.Serum thyroglobulin reference intervals in regions with adequate and more than adequate iodine intake.[J].MEDICINE.2016,95(48):doi:10.1097/MD.0000000000005273.
APA：
Wang Zhaojun,Zhang Hanyi,Zhang Xiaowen,Sun Jie,Han Cheng...&Teng Weiping.(2016).Serum thyroglobulin reference intervals in regions with adequate and more than adequate iodine intake..MEDICINE,95,(48)
MLA：
Wang Zhaojun,et al."Serum thyroglobulin reference intervals in regions with adequate and more than adequate iodine intake.".MEDICINE 95..48(2016)
