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Anti-fatigue activity of polysaccharides extract from Radix Rehmanniae Preparata.

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机构： [1]Department of Traditional Chinese Medicine, Southern Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China [2]School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong 510515, China [3]Department of Science and Technology, Southern Medical University, Guangzhou, Guangdong 510515, China

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关键词： Radix Rehmanniae Preparata Polysaccharides Anti-fatigue

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The anti-fatigue effects of the Radix Rehmanniae Preparata polysaccharides (RRPP) were studied in mice. The RRPP were orally administered at doses of 50, 100 and 200 mg/kg for 4 weeks and the anti-fatigue activity was evaluated using a weight-loaded swimming test, along with the determination of serum urea nitrogen (SUN), hepatic glycogen and blood lactic acid (BLA) contents. The results showed that there was no significant difference in the body weight of mice in the three RRPP groups compared with the negative control group during initial, intermediate and terminal stages in the experiment (p>0.05). The ratio of exhausting swimming time was obviously increased 31.48% (p<0.05) and 61.51% (p<0.01) in the middle-dose group and the high-dose RRPP group, respectively. The BLA and SUN levels were decreased in middle-dose and high-dose RRPP groups (p<0.01). Hepatic glycogen level was increased in three RRPP treated groups (p<0.01). Therefore, RRPP may be responsible for the pharmacological effect of anti-fatigue of Radix Rehmanniae Preparata. The mechanism was related to the increase of the storage of hepatic glycogen and the decrease of the accumulation of SUN and BLA. Crown Copyright © 2011. Published by Elsevier B.V. All rights reserved.

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出版当年[2011]版：

大类 | 3 区生物

小类 | 4 区生化与分子生物学

最新[2025]版：

大类 | 2 区

生物学

小类 | 2 区生化与分子生物学 2 区应用化学 2 区高分子科学

第一作者：

第一作者机构： [1]Department of Traditional Chinese Medicine, Southern Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China [2]School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong 510515, China

通讯作者：

通讯机构： [1]Department of Traditional Chinese Medicine, Southern Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China [2]School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong 510515, China [*1]Department of Traditional Chinese Medicine, Southern Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou 510515, China.

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