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Strontium Modified Calcium Sulfate Hemihydrate Scaffold Incorporating Ginsenoside Rg1/Gelatin Microspheres for Bone Regeneration

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资源类型：
WOS体系：
Pubmed体系：

收录情况： ◇ SCIE ◇ EI

作者：
Peng Luo[1,2] * ; Lan Yu[3] * ; Qiang Lin[4] ; Changde Wang[5] ; Dazhi Yang[1,2] ; Shuo Tang[6] ;
机构： [1]Department of Orthopaedics, Huazhong University of Science and Technology Union Shenzhen Hospital (Nanshan Hospital), Shenzhen, China [2]Department of Orthopaedics, The 6th Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen, China [3]Department of Laboratory, Huazhong University of Science and Technology Union Shenzhen Hospital (Nanshan Hospital), Shenzhen, China [4]Department of Orthopaedics, Guangdong Hospital of Traditional Chinese Medicine, Guangzhou, China [5]Department of Geriatric Orthopeadics, Shenzhen Pingle Orthopaedic Hospital, Shenzhen, China [6]Department of Orthopaedics, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China
出处：
DOI： 10.3389/fbioe.2020.00888
ISSN：

关键词： bone defect calcium sulfate hemihydrate (α-CaS) gelatin microspheres Ginsenoside Rg1 (Rg1) strontium (Sr)

摘要：
The aim of this study was to prepare a promising biomaterial for bone tissue repair and regeneration. The Strontium – calcium sulfate hemihydrate (Sr-α-CaS) scaffold incorporating gelatin microspheres (GMs) encapsulated with Ginsenoside Rg1 (Rg1) was designed. The scaffolds of Rg1/GMs/Sr-α-CaS showed sustained release of Rg1, good biocompatibility and ability of promoting osteogenic differentiation and angiogenesis in vitro. The scaffolds were implanted into animal model of cranial bone defect to characterize bone tissue repair and regeneration in vivo. From the images of Micro-CT, it was obvious that the most bone tissue was formed in Rg1/GMs/Sr-α-CaS group in 12 weeks. New bone structure, collagen and mineralization were analyzed with staining of HE, Masson and Safranin O-Fast green and showed good distribution. The expression of osteocalcin of Rg1/GMs/Sr-α-CaS indicated new bone formation in defect site. The results revealed that synergy of Rg1 and Sr showed the best effect of bone repair and regeneration, which provided a new candidate for bone defect repair in clinic. © Copyright © 2020 Luo, Yu, Lin, Wang, Yang and Tang.

基金：
Funding. This study was supported financially by the Science and Technology Project of Shenzhen (Nos. JCYJ20190808102203649 and 20190802113709023), the Medical Science and Technology Foundation of Guangdong (No. A2020600), and the Science and Technology Project of Shenzhen Nanshan District (No. 2018050).
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2019]版：
大类 | 2 区 工程技术
小类 | 3 区 综合性期刊
最新[2025]版：
大类 | 3 区 生物学
小类 | 3 区 生物工程与应用微生物 4 区 工程：生物医学
JCR分区：
出版当年[2018]版：
Q1 MULTIDISCIPLINARY SCIENCES
最新[2023]版：
Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Q2 ENGINEERING, BIOMEDICAL

影响因子： 最新[2023版] 最新五年平均 出版当年[2018版] 出版当年五年平均 出版前一年[2017版] 出版后一年[2019版]

第一作者：
第一作者机构： [1]Department of Orthopaedics, Huazhong University of Science and Technology Union Shenzhen Hospital (Nanshan Hospital), Shenzhen, China [2]Department of Orthopaedics, The 6th Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen, China
共同第一作者：
通讯作者：
通讯机构： [1]Department of Orthopaedics, Huazhong University of Science and Technology Union Shenzhen Hospital (Nanshan Hospital), Shenzhen, China [2]Department of Orthopaedics, The 6th Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen, China
推荐引用方式(GB/T 7714)：
Peng Luo,Lan Yu,Qiang Lin,et al.Strontium Modified Calcium Sulfate Hemihydrate Scaffold Incorporating Ginsenoside Rg1/Gelatin Microspheres for Bone Regeneration[J].FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY.2020,8:doi:10.3389/fbioe.2020.00888.
APA：
Peng Luo,Lan Yu,Qiang Lin,Changde Wang,Dazhi Yang&Shuo Tang.(2020).Strontium Modified Calcium Sulfate Hemihydrate Scaffold Incorporating Ginsenoside Rg1/Gelatin Microspheres for Bone Regeneration.FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY,8,
MLA：
Peng Luo,et al."Strontium Modified Calcium Sulfate Hemihydrate Scaffold Incorporating Ginsenoside Rg1/Gelatin Microspheres for Bone Regeneration".FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY 8.(2020)

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