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The Cumulative Rate of SARS-CoV-2 Infection in Chinese Hemodialysis Patients.

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机构: [1]State Key Laboratory of Organ Failure Research, National Clinical Research Center for Kidney Disease, Guangzhou, China [2]Nanfang Hospital, Southern Medical University, Guangzhou, China [3]Department of Nephrology, The First People’s Hospital ofFoshan, Foshan, China [4]The People`s Hospital of Honghu, Honghu, China [5]Department of Nephrology, The First People’sHospital of Jingzhou, Jingzhou, China [6]Department of Nephrology, Jingzhou Central Hospital, Jingzhou, China [7]Departmentof Nephrology, Honghu Traditional Chinese Medicine Hospital, Honghu, China [8]Department of Nephrology, The SecondPeople’s Hospital of Honghu, Honghu, China [9]Department of Nephrology, Guizhou Provincial People’s Hospital, GuizhouUniversity, Guiyang, China [10]Bureau of Medical Administration, Health Commission of Guangdong, Guangdong, China [11]Wuhan Kingmed Medical Laboratory, Wuhan, China [12]Key Laboratory of Molecular Biology on Infectious Diseases, Ministryof Education, Chongqing Medical University, Chongqing, China [13]Guangzhou Regenerative Medicine and HealthGuangdong Laboratory, Guangzhou, China
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关键词: antibody COVID-19 hemodialysis

摘要:
There is a paucity of information regarding severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in patients undergoing maintenance hemodialysis. We aimed to estimate the cumulative attack rate of SARS-CoV-2 in hemodialysis patients in China using a serological test. We enrolled all hemodialysis patients from 8 hemodialysis facilities in Honghu and Jingzhou of Hubei province and Guangzhou and Foshan of Guangdong province in China. We screened these patients for SARS-CoV-2 infection by both a reverse-transcriptase polymerase chain reaction (RT-PCR) test for viral RNA and a serological test for IgG and IgM antibodies. Data on demographics and clinical characteristics were collected via case report forms. We also enrolled the health care workers from the participating hospitals and compared the seropositive rate between hemodialysis patients and health care workers in the same region. Among 1542 hemodialysis patients, 5 (0.32%) and 51 (3.3%) were tested positive by the RT-PCR test and the serological test, respectively. The seropositive rate in Hubei (3.6%) was higher than that in Guangdong (2.8%), although the difference was not statistically significant (P = 0.5). Most of the seropositive patients were asymptomatic. Independent risk factors for SARS-CoV-2 infection were being older than 65 years, having manifestation of lung infection in imaging examinations, and having a lower level of serum albumin. In comparison, the seropositive rate in 3205 health care workers was 1.2%,which was significantly lower than that observed in the hemodialysis patients (P < .001). The cumulative rate of SARS-CoV-2 infection in hemodialysis patients in China was high at 3.3%. Serological test detected 10 times more cases of SARS-CoV-2 infection than the RT-PCR test and should be the preferred tool for estimating the prevalence of coronavirus disease 2019 (COVID-19). © 2020 International Society of Nephrology. Published by Elsevier Inc.

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大类 | 2 区 医学
小类 | 2 区 泌尿学与肾脏学
第一作者:
第一作者机构: [1]State Key Laboratory of Organ Failure Research, National Clinical Research Center for Kidney Disease, Guangzhou, China [2]Nanfang Hospital, Southern Medical University, Guangzhou, China
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通讯作者:
通讯机构: [1]State Key Laboratory of Organ Failure Research, National Clinical Research Center for Kidney Disease, Guangzhou, China [2]Nanfang Hospital, Southern Medical University, Guangzhou, China [13]Guangzhou Regenerative Medicine and HealthGuangdong Laboratory, Guangzhou, China [*1]Renal Division, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou 510515, China
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