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Radix astragali inhibits the down-regulation of connexin 26 in the stria vascularis of the guinea pig cochlea after acoustic trauma

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机构： [1]Department of Otolaryngology, Guangzhou General Hospital of Guangzhou Military Command, Liu Hua Road 111, Guangzhou, 510010, China [2]Department of Pathology, The Second Hospital Affiliated To Guangzhou Traditional Chinese Medical University, Da De Road 111, Guangzhou, 510120, China [3]Medical Research Center, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, 510010, China

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关键词： Cochlea Connexin 26 Hearing loss Impulse noise Radix astragali Reactive oxygen species

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Connexin 26 (cx26) plays an important role in the intercellular signaling and is related to K+ metabolism in stria vascularis (SV). Reactive oxygen species (ROS) are negative regulators of cx26, reducing intercellular coupling in cochlea. ROS plays an important role in acoustic trauma. Radix astragali is a natural antioxidant that decreases impulse noise-induced hearing loss through its ability to inhibit ROS. The purpose of this study was to investigate if radix astragali has the potential to reduce the change of cx26 in SV from impulse noise. Guinea pigs in the experimental group were administered radix astragali intraperitoneally. Auditory thresholds were assessed by sound-evoked auditory brainstem response (ABR) at click and tone bursts of 8, 16 and 32 kHz, 24 h before and 72 h after exposure to impulse noise. 4-Hydroxynonenal, cx26 and KCNQ1 were determined immunohistochemically in SV. SV was analyzed by transmission electron microscopy. Radix astragali significantly reduced the ABR deficits and the SV damage, and decreased the shifts of the expression of cx26 and KCNQ1 in the SV. These results suggest that the beneficial effect of radix astragali on impulse noise-induced hearing loss may be also due to its ability to reduce the change of cx26 in SV. © 2014, Springer-Verlag Berlin Heidelberg.

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出版当年[2014]版：

大类 | 4 区医学

小类 | 3 区耳鼻喉科学

最新[2025]版：

大类 | 3 区医学

小类 | 3 区耳鼻喉科学

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第一作者机构： [1]Department of Otolaryngology, Guangzhou General Hospital of Guangzhou Military Command, Liu Hua Road 111, Guangzhou, 510010, China

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