机构：[1]Guangzhou University of Chinese Medicine, Guangzhou, GuangdongProvince, China[2]Department of Pain, Linyi People’s Hospital, Linyi,Shandong Province, China[3]Department of Sports Medicine, Linyi TraditionalChinese Medicine Hospital, Linyi, Shandong Province, China[4]Department ofOrthopedics, Linyi People’s Hospital, Jie Fang Road East, No .27, Linyi 276003,Shandong Province, China
The neuropeptide vasoactive intestinal peptide is a 28-amino acid neuropeptide that has been shown to stimulate bone repair and angiogenesis. The purpose of this study was to explore the potential role of serum VIP concentration in osteonecrosis of femoral trauma (ONFH).
One hundred five patients diagnosed with non-traumatic ONFH and 103 healthy individuals were enrolled in our study. Serum VIP, tumor necrosis factor-α (TNF-α), interluekin-1 beta (IL-1β), and macrophage colony-stimulating factor (M-CSF) levels also were detected using the commercial ELISA kit. Radiographic progression was evaluated using FICAT classification. The clinical severity of ONFH was assessed by visual analog score (VAS) and Harris Hip Score (HHS). Receiver-operating characteristic (ROC) curve was performed to test the potential diagnostic value of VIP in radiographic progression.
The serum VIP level of patients with non-traumatic ONFH was significantly lower than that of healthy controls. There was no significant difference between the alcohol group, the steroid-induction group, and the idiopathic group. Serum VIP levels were significantly higher in ONFH patients with femoral head pre-collapse stage than collapse stage. Serum VIP levels were significantly lower. FICAT 4 non-traumatic ONFH patients had significantly lower serum concentrations of VIP when compared with FICAT 3 and FICAT 2. Moreover, serum VIP levels were significantly lower in ONFH patients with FICAT 3 than FICAT 2. Serum VIP levels were negatively related to FICAT stage. In addition, serum VIP levels were negatively associated with VAS score and positively associated with HHS score. Last, we found serum VIP levels were negatively associated with serum TNF-α and IL-1β levels. ROC curve analysis indicated that decreased serum VIP could serve as a decent biomarker with regard to the diagnosis of radiographic progression.
Attenuated serum VIP concentrations are correlated with disease severity of non-traumatic ONFH. Decreased serum VIP may serve as a potential indicator of non-traumatic ONFH.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2020]版：
大类|4 区医学
小类|4 区骨科
最新[2025]版：
大类|3 区医学
小类|3 区骨科
第一作者：
第一作者机构：[1]Guangzhou University of Chinese Medicine, Guangzhou, GuangdongProvince, China[2]Department of Pain, Linyi People’s Hospital, Linyi,Shandong Province, China
通讯作者：
推荐引用方式(GB/T 7714)：
Liu Ming,Zhao Gan,Wei Biao-Fang.Attenuated serum vasoactive intestinal peptide concentrations are correlated with disease severity of non-traumatic osteonecrosis of femoral head.[J].Journal of orthopaedic surgery and research.2021,16(1):325.doi:10.1186/s13018-021-02486-3.
APA：
Liu Ming,Zhao Gan&Wei Biao-Fang.(2021).Attenuated serum vasoactive intestinal peptide concentrations are correlated with disease severity of non-traumatic osteonecrosis of femoral head..Journal of orthopaedic surgery and research,16,(1)
MLA：
Liu Ming,et al."Attenuated serum vasoactive intestinal peptide concentrations are correlated with disease severity of non-traumatic osteonecrosis of femoral head.".Journal of orthopaedic surgery and research 16..1(2021):325
