Pancreatic cancer (PC) is a devasting disease of which mortality almost parallels its incidence. Pancreatic cancer tissue may express aberrantly methylated NPTX2, but it is unclear what the consequences of this are. We analysed 9 studies, with a total of 927 patients, to identify if the detection of methylated NPTX2 have sufficient sensitivity and specificity to identify pancreatic cancer from other benign pancreatic diseases. The majority studies obtained samples from pancreatic juice by endoscopy or surgery and composed of population with chronic pancreatitis, benign cystic lesion, intraductal papillary mucinous neoplasm, healthy controls. Our results demonstrated that the diagnostic value of methylated NPTX2 are of widely various sensitivity and specificity and it shown higher specificity in differentiate PC from benign diseases. The lab method of QMSP has higher specificity than MSP in detecting the indicator. The variable sensitivity of methylated NPTX2 was multifactorial and it must be promoted before applied as screening test in clinical practice.This article is protected by copyright. All rights reserved.