机构：[1]Shenzhen Bao'an Traditional Chinese Medicine Hospital Group, Shenzhen 518133, China.[2]Shenzhen Bao'an Traditional Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Shenzhen 518033, China.[3]Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, Engineering and Technological Research Centre for Drug Carrier Development, Department of Biomedical Engineering, Jinan University, Guangzhou 510632, China.[4]Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China.
Infection is the major reason that people die from burns; however, traditional medical dressings such as gauze cannot restrain bacterial growth and enhance the healing process. Herein, an organic- and inorganic-base hydrogel with antibacterial activities was designed and prepared to treat burn wounds. Oxidized dextran (ODex) and adipic dihydrazide grafted hyaluronic acid (HA-ADH) were prepared, mixed with quaternized chitosan (HACC) and silver nanoparticles to fabricate Ag@ODex/HA-ADH/HACC hydrogel. The hydrogel, composed of nature biomaterials, has a good cytocompatibility and biodegradability. Moreover, the hydrogel has an excellent antibacterial ability and presents fast healing for burn wounds compared with commercial Ag dressings. The Ag@ODex/HA-ADH/HACC hydrogel will be a promising wound dressing to repair burn wounds and will significantly decrease the possibility of bacterial infection.
基金：
National Natural Science Foundation of China (81972080),
the Research Program of PLA (20QNPY083, CGZ16C004), the Science and Technology Planning Project
of Guangdong Province (2017B030314139), the Natural Science Foundation of Guangdong Province
(2015A030312004), the Science and Technology Planning Project of Guangzhou (202002030304) and the
Medical Research Foundation of Guangdong Province (A2019228).
第一作者机构：[1]Shenzhen Bao'an Traditional Chinese Medicine Hospital Group, Shenzhen 518133, China.
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Chen Xushan,Zhang Huimin,Yang Xin,et al.Preparation and Application of Quaternized Chitosan- and AgNPs-Base Synergistic Antibacterial Hydrogel for Burn Wound Healing.[J].MOLECULES.2021,26(13):doi:10.3390/molecules26134037.
APA：
Chen Xushan,Zhang Huimin,Yang Xin,Zhang Wuhong,Jiang Ming...&Liu Hanjiao.(2021).Preparation and Application of Quaternized Chitosan- and AgNPs-Base Synergistic Antibacterial Hydrogel for Burn Wound Healing..MOLECULES,26,(13)
MLA：
Chen Xushan,et al."Preparation and Application of Quaternized Chitosan- and AgNPs-Base Synergistic Antibacterial Hydrogel for Burn Wound Healing.".MOLECULES 26..13(2021)
