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Injectable multifunctional chitosan/dextran-based hydrogel accelerates wound healing in combined radiation and burn injury

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资源类型：
Pubmed体系：
作者：
Shen Jintao[1] * ; Jiao Wencheng[1,2] * ; Chen Ziyuan[1] ; Wang Chunqing[1,3] ; Song Xingshuang[1,3] ; Ma Lei[1] ; Tang Ziyan[1] ; Yan Wenrui[1,4] ; Xie Hua[1,4] ; Yuan Bochuan[1] ; Wang Chenyun[5] ; Dai Jing[6] ; Sun Yunbo[1,2,*1] ; Du Lina[1,2,3,*1] ; Jin Yiguang[1,4,*1] ;
机构： [1]Beijing Institute of Radiation Medicine, Beijing 100850, China [2]Hebei University, Baoding 071002, China [3]Shandong University of Traditional Chinese Medicine, Jinan 250355, China [4]Guangdong Pharmaceutical University, Guangzhou 510006, China [5]The Fourth Clinical Center Affiliated to Chinese PLA General Hospital, Beijing 100048, China [6]Information Department, General Hospital of Western War Zone, Chengdu 610083, China
出处：
DOI： 10.1016/j.carbpol.2023.121024
ISSN：

关键词： Injectable hydrogel Gallic acid Antioxidant Antibacterial Combined radiation and burn injury (CRBI) Wound healing

摘要：
Clinical wound management of combined radiation and burn injury (CRBI) remains a huge challenge due to serious injuries induced by redundant reactive oxygen species (ROS), the accompanying hematopoietic, immunologic suppression and stem cell reduction. Herein, the injectable multifunctional Schiff base cross-linked with gallic acid modified chitosan (CSGA)/oxidized dextran (ODex) hydrogels were rationally designed to accelerate wound healing through elimination of ROS in CRBI. CSGA/ODex hydrogels, fabricated by mixing solutions of CSGA and Odex, displayed good self-healing ability, excellent injectability, strong antioxidant activity, and favorable biocompatibility. More importantly, CSGA/ODex hydrogels exhibited excellent antibacterial properties, which is facilitated for wound healing. Furthermore, CSGA/ODex hydrogels significantly suppressed the oxidative damage of L929 cells in an H2O2-induced ROS microenvironment. The recovery of mice with CRBI in mice demonstrated that CSGA/ODex hydrogels significantly reduced the hyperplasia of epithelial cells and the expression of proinflammatory cytokine, and accelerated wound healing which was superior to the treatment with commercial triethanolamine ointment. In conclusion, the CSGA/ODex hydrogels as a wound dressing could accelerate the wound healing and tissue regeneration of CRBI, which provides great potential in clinical treatment of CRBI.Copyright © 2023. Published by Elsevier Ltd.

基金：
This work was financially supported by Beijing Natural Science Foundation (L222126).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 1 区 化学
小类 | 1 区 应用化学 1 区 高分子科学 1 区 有机化学
最新[2025]版：
大类 | 1 区 化学
小类 | 1 区 应用化学 1 区 有机化学 1 区 高分子科学
第一作者：
第一作者机构： [1]Beijing Institute of Radiation Medicine, Beijing 100850, China
共同第一作者：
通讯作者：
通讯机构： [1]Beijing Institute of Radiation Medicine, Beijing 100850, China [2]Hebei University, Baoding 071002, China [3]Shandong University of Traditional Chinese Medicine, Jinan 250355, China [4]Guangdong Pharmaceutical University, Guangzhou 510006, China [*1]Beijing Institute of Radiation Medicine, Beijing 100850, China.
推荐引用方式(GB/T 7714)：
Shen Jintao,Jiao Wencheng,Chen Ziyuan,et al.Injectable multifunctional chitosan/dextran-based hydrogel accelerates wound healing in combined radiation and burn injury[J].Carbohydrate polymers.2023,316:121024.doi:10.1016/j.carbpol.2023.121024.
APA：
Shen Jintao,Jiao Wencheng,Chen Ziyuan,Wang Chunqing,Song Xingshuang...&Jin Yiguang.(2023).Injectable multifunctional chitosan/dextran-based hydrogel accelerates wound healing in combined radiation and burn injury.Carbohydrate polymers,316,
MLA：
Shen Jintao,et al."Injectable multifunctional chitosan/dextran-based hydrogel accelerates wound healing in combined radiation and burn injury".Carbohydrate polymers 316.(2023):121024

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