详情页 - 广东省中医院知识库

当前位置：首页 > 详情页

MIER3 induces epithelial-mesenchymal transition and promotes breast cancer cell aggressiveness via forming a co-repressor complex with HDAC1/HDAC2/Snail.

文献详情

资源类型：

Pubmed体系：

作者：

机构： [1]Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China [2]Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China [3]Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China [4]Department of Traditional Chinese Medicine, Scientific Research Platform, The Second School of Clinical Medicine, Guangdong Medical University, Dongguan, 523808, China

出处：

DOI：

ISSN：

关键词： MIER3 Breast cancer EMT Snail HDAC

摘要：

Breast cancer is one of the most frequently diagnosed cancers and the leading cause of cancer death in women. MIER3 (Mesoderm induction early response 1, family member3) is considered as a potential oncogene for breast cancer. However, the role of MIER3 in breast cancer remain largely unknown. The expression of MIER3 was detected and the relationship between its expression and clinicopathological characteristics was also analyzed. The effect of MIER3 on proliferation and migration of breast cancer cells was detected in vitro and in vivo. Western blot, IF, and Co-IP were employed to detect the relationship between MIER3, HDAC1, HDAC2, and Snail. ChIP assay was performed to determine the binding of MIER3/HDAC1/HDAC2/Snail complex to the promoter of E-cadherin. In this study, we found that MIER3 was upregulated in breast cancer tissue and closely associated with poor prognosis of patients. MIER3 could promote the proliferation, migration, and epithelial-mesenchymal transition (EMT) of breast cancer cells. Further studies showed that MIER3 interacted with HDAC1/HDAC2 and Snail to form a repressive complex which could bind to E-cadherin promoter and was related to its deacetylation. Our study concluded that MIER3 was involved in forming a co-repressor complex with HDAC1/HDAC2/Snail to promote EMT by silencing E-cadherin.Copyright © 2021 Elsevier Inc. All rights reserved.

基金：

语种：

PubmedID：

中科院(CAS)分区：

出版当年[2020]版：

大类 | 3 区医学

小类 | 3 区肿瘤学 4 区细胞生物学

最新[2025]版：

大类 | 3 区生物学

小类 | 4 区细胞生物学 4 区肿瘤学

第一作者：

第一作者机构： [1]Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China [2]Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China

共同第一作者：

通讯作者：

通讯机构： [1]Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China [2]Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China [*1]Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.

推荐引用方式(GB/T 7714)：

APA：

MLA：

MIER3 induces epithelial-mesenchymal transition and promotes breast cancer cell aggressiveness via forming a co-repressor complex with HDAC1/HDAC2/Snail.

文献详情

相关文献