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MeCP2 inhibits proliferation and migration of breast cancer via suppression of epithelial-mesenchymal transition.

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收录情况： ◇ SCIE

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机构： [1]Department of Anatomy & Histology, School of Basic Medical Sciences, Shenzhen University Health Science Centre, Shenzhen, China [2]Guangdong Provincial People’s Hospital’s Nanhai Hospital, Foshan, China [3]Department of Dermatology, Shenzhen University General Hospital, Shenzhen, China [4]National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang, China

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关键词： breast cancer epithelial-mesenchymal transition (EMT) invasion Methyl-CpG-binding protein 2 (MeCP2)

摘要：

Methyl-CpG-binding protein 2 (MeCP2) is an important epigenetic regulator for normal neuronal maturation and brain glial cell function. Additionally, MeCP2 is also involved in a variety of cancers, such as breast, prostate, lung, liver and colorectal. However, whether MeCP2 contributes to the progression of breast cancer remains unknown. In the present study, we investigated the role of MeCP2 in cell proliferation, migration and invasion in vitro. We found that knockdown of MeCP2 inhibited expression of epithelial-mesenchymal transition (EMT)-related markers in breast cancer cell lines. In conclusion, our study suggests that MeCP2 inhibits proliferation and invasion through suppression of the EMT pathway in breast cancer. © 2020 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.

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出版当年[2019]版：

大类 | 2 区医学

小类 | 2 区医学：研究与实验 3 区细胞生物学

最新[2025]版：

大类 | 3 区医学

小类 | 3 区细胞生物学 3 区医学：研究与实验

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出版当年[2018]版：

Q1 MEDICINE, RESEARCH & EXPERIMENTAL Q2 CELL BIOLOGY

最新[2023]版：

Q2 CELL BIOLOGY Q2 MEDICINE, RESEARCH & EXPERIMENTAL

影响因子： 4.3 最新[2023版] 5.1 最新五年平均 4.658 出版当年[2018版] 4.408 出版当年五年平均 4.302 出版前一年[2017版] 4.486 出版后一年[2019版]

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第一作者机构： [1]Department of Anatomy & Histology, School of Basic Medical Sciences, Shenzhen University Health Science Centre, Shenzhen, China

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通讯作者：

通讯机构： [4]National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang, China [*1]National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang 330006, China.

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