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Multi-omic analysis of altered transcriptome and epigenetic signatures in the UV-induced DNA damage response.

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收录情况： ◇ SCIE

作者：
Liu Jiena[1,2] * ; Liu Lingyun[3] * ; He Jin[4] * ; Xu Yingying[1,2] ; Wang Yuming[1,2,*1] ;
机构： [1]Institute of Neuroscience and the Second Affiliated Hospital of Guangzhou Medical University, Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, Guangzhou 510260, China [2]Key Laboratory of Neurological Function and Health, School of Basic Medical Science, Guangzhou Medical University, Guangzhou 511436, China [3]School of Basic Medical Science, Guangzhou University of Chinese Medicine, Guangzhou 510006, China [4]School of Management, Guangdong University of Technology, Guangzhou 510520, China
出处：
DOI： 10.1016/j.dnarep.2021.103172
ISSN：

关键词： DNA damage response UV-irradiation TC-NER Gene expression DNA methylation m6A RNA methylation

摘要：
The transcription-related DNA damage response was visualized on a genome-wide scale with great spatial and temporal resolution. Upon UV irradiation, a small proportion of mature RNA transcripts undergo changes, with significant activation of DNA repair factors. Notably, an increase of chromatin accessibility is observed at the immediate early recovery phase and serves as binding sites for selective stage-specific transcription factors. Whole genome analysis of DNA methylation (5mC) delineates pervasive dynamics during DNA repair process, and hypomethylation at gene bodies and 3'UTR is accompanied by induction of DNA damage response genes. Furthermore, temporal-specific m6A RNA methylation has been defined and appears to affect DNA repair by modulation of translation. These findings provide a resource for identifying players required for transcription-coupled nucleotide excision repair and reveal insights into the epigenetic regulation of the transcriptional programs in response to genotoxic stress.Copyright © 2021. Published by Elsevier B.V.

基金：
the National Natural Science Foundation of China [grant number 81571092], the Project of Department of Education of Guangdong Province of China [grant number 2020KTSCX099], the Project of Guangzhou Municipal Science and Technology Bureau [grant number 202102080216], and the Talent Training Program of the Basic Medical College of Guangzhou Medical University [grant number JCXKJS2021B01] to Y.W., and by a grant to L.L. from the Science and Technology Planning Project of Guangzhou [grant number 201707010319].
语种：
外文
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中科院(CAS)分区：
出版当年[2020]版：
大类 | 2 区 生物
小类 | 2 区 毒理学 3 区 遗传学
最新[2025]版：
大类 | 3 区 生物学
小类 | 3 区 遗传学 3 区 毒理学
JCR分区：
出版当年[2019]版：
Q2 TOXICOLOGY Q2 GENETICS & HEREDITY
最新[2023]版：
Q2 GENETICS & HEREDITY Q2 TOXICOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2019版] 出版当年五年平均 出版前一年[2018版] 出版后一年[2020版]

第一作者：
第一作者机构： [1]Institute of Neuroscience and the Second Affiliated Hospital of Guangzhou Medical University, Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, Guangzhou 510260, China [2]Key Laboratory of Neurological Function and Health, School of Basic Medical Science, Guangzhou Medical University, Guangzhou 511436, China
共同第一作者：
通讯作者：
通讯机构： [1]Institute of Neuroscience and the Second Affiliated Hospital of Guangzhou Medical University, Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, Guangzhou 510260, China [2]Key Laboratory of Neurological Function and Health, School of Basic Medical Science, Guangzhou Medical University, Guangzhou 511436, China [*1]Institute of Neuroscience and the Second Affiliated Hospital of Guangzhou Medical University, Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, Guangzhou 510260, China.
推荐引用方式(GB/T 7714)：
Liu Jiena,Liu Lingyun,He Jin,et al.Multi-omic analysis of altered transcriptome and epigenetic signatures in the UV-induced DNA damage response.[J].DNA REPAIR.2021,106:doi:10.1016/j.dnarep.2021.103172.
APA：
Liu Jiena,Liu Lingyun,He Jin,Xu Yingying&Wang Yuming.(2021).Multi-omic analysis of altered transcriptome and epigenetic signatures in the UV-induced DNA damage response..DNA REPAIR,106,
MLA：
Liu Jiena,et al."Multi-omic analysis of altered transcriptome and epigenetic signatures in the UV-induced DNA damage response.".DNA REPAIR 106.(2021)

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