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Xanthomicrol suppresses human hepatocellular carcinoma cells migration and invasion ability via Μu-opioid receptor.

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机构： [1]School of Basic Medical Sciences, Youjiang Medical University for Nationalities, Baise, Guangxi, P.R. China. [2]Department of pharmacy, Langdong Hospital of Guangxi Medical University, Nanning, P.R. China. [3]Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, P.R. China. [4]Medical College, Guangxi University, Nanning, P.R.China. [5]Guangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory of Wild Animal Conservation and Utilization, Institute of Zoology, Guangdong Academy of Sciences, Guangzhou, Guangdong, P.R. China. [6]Hubei Key Laboratory of Medical Information Analysis and Tumor Diagnosis & Treatment, South-Central University for Nationalities, Wuhan, Hubei, P.R. China. [7]Hubei Key Laboratory of Wudang Local Chinese Medicine Research, Hubei University of Medicine, Shiyan, Hubei, P.R. China.

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关键词： Xanthomicrol Huh7 cells migration invasion Μu opioid receptor

摘要：

Xanthomicrol is one of the methoxylated flavones and a promising cancer chemopreventive agent, but its anti-migration and anti-invasion ability on human hepatocellular carcinoma (HCC) remains unknown.This study aims to explore Xanthomicrol's effects on migration and invasion ability of the human HCC Huh7 cell line.Viability of Huh7 cells was measured by cell counting kit-8 (CCK8) assay. Cell apoptosis was assayed with flow cytometry analysis. The ability of migration and invasion of Huh7 cells was then detected through Transwell assays. Epithelial-mesenchymal transition (EMT)-related proteins were also detected through Western blot.Xanthomicrol inhibits the migration and invasion of Huh7 cells. The overexpression of Μu-opioid receptor (MOR) increases Huh7 cells' proliferation and enhances migration and invasion ability, while xanthomicrol treatment decreases the expression of MOR. Moreover, xanthomicrol can reverse migration, invasion and EMT-related protein expression by overexpressed MOR.These results suggest that xanthomicrol is a potential MOR antagonist, and it possesses potent anti-migration and anti-invasion ability on Huh7 cells.© The Author(s) 2021. Published by Oxford University Press on behalf of the Royal Pharmaceutical Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

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出版当年[2020]版：

大类 | 3 区医学

小类 | 3 区药学

最新[2025]版：

大类 | 4 区医学

小类 | 4 区药学

第一作者：

第一作者机构： [1]School of Basic Medical Sciences, Youjiang Medical University for Nationalities, Baise, Guangxi, P.R. China. [2]Department of pharmacy, Langdong Hospital of Guangxi Medical University, Nanning, P.R. China.

通讯作者：

通讯机构： [1]School of Basic Medical Sciences, Youjiang Medical University for Nationalities, Baise, Guangxi, P.R. China. [2]Department of pharmacy, Langdong Hospital of Guangxi Medical University, Nanning, P.R. China. [3]Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, P.R. China. [4]Medical College, Guangxi University, Nanning, P.R.China. [*1]School of Basic Medical Sciences, Youjiang Medical University for Nationalities, Baise 533000, Guangxi, P.R. China.Medical College, Guangxi University, Nanning 530004, Guangxi, P.R. China.

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Xanthomicrol suppresses human hepatocellular carcinoma cells migration and invasion ability via Μu-opioid receptor.

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